Que Diana-Lynn S, Jamora Roland Dominic G
Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines.
Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines; Movement Disorders Service, Institute for Neurosciences, St. Luke's Medical Center, Quezon City and Global City, Philippines; Department of Neurosciences, College of Medicine-Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Clin Ther. 2021 Jan;43(1):e19-e31. doi: 10.1016/j.clinthera.2020.11.009. Epub 2020 Dec 3.
Parkinson disease (PD) medications are not readily available in all countries. Citicoline increases dopamine synthesis and inhibits dopamine uptake. This systematic review aims to synthesize current existing evidence on the efficacy of citicoline adjunctive therapy in improving PD symptoms.
An extensive literature search of Scopus, Embase, PubMed, Cochrane Library, and Google Scholar was conducted for articles published on or before December 31, 2019. The studies were screened and selected by 2 independent reviewers. We included all studies that explored the efficacy of citicoline as an adjunct therapy in PD.
A total of 7 studies (2 crossover, 3 randomized controlled, and 2 open prospective studies) were included. Despite the varied outcome tools, this review found that patients with PD who were taking citicoline had significant improvement in rigidity, akinesia, tremor, handwriting, and speech. Citicoline allowed effective reduction of levodopa by up to 50%. Significant improvement in cognitive status evaluation was also noted with citicoline adjunctive therapy.
Citicoline adjuvant therapy has beneficial effects as an adjuvant therapy in patients with PD. However, due to the heterogeneity of the studies, there is a need for more high-quality studies.
并非所有国家都能轻易获得帕金森病（PD）药物。胞磷胆碱可增加多巴胺合成并抑制多巴胺摄取。本系统评价旨在综合现有关于胞磷胆碱辅助治疗改善PD症状疗效的证据。
对Scopus、Embase、PubMed、Cochrane图书馆和谷歌学术进行广泛文献检索，查找2019年12月31日或之前发表的文章。由2名独立评审员对研究进行筛选和选择。我们纳入了所有探讨胞磷胆碱作为PD辅助治疗疗效的研究。
共纳入7项研究（2项交叉研究、3项随机对照研究和2项开放前瞻性研究）。尽管结局工具各不相同，但本评价发现，服用胞磷胆碱的PD患者在强直、运动不能、震颤、书写和言语方面有显著改善。胞磷胆碱可使左旋多巴有效减少高达50%。胞磷胆碱辅助治疗在认知状态评估方面也有显著改善。
胞磷胆碱辅助治疗对PD患者作为辅助治疗有有益作用。然而，由于研究的异质性，需要更多高质量的研究。
