硫糖铝预防消化性溃疡复发的疗效——与西咪替丁的双盲多中心研究
Efficacy of sucralfate in the prevention of recurrence of peptic ulcer--double blind multicenter study with cimetidine.
作者信息
Takemoto T, Kimura K, Okita K, Tsuneoka K, Ohshiba S, Namiki M, Fukuchi S, Miyake T, Fukutomi H, Okazaki Y
机构信息
Department of Internal Medicine I, Yamaguchi University, Japan.
出版信息
Scand J Gastroenterol Suppl. 1987;140:49-60.
A double blind, multicenter, six-month maintenance study was performed to assess the efficacy and safety of sucralfate (S), cimetidine (C), and their combination (S + C) in the prevention of peptic ulcer recurrence in a six-month observation period. 127 patients with gastric ulcer (GU) (group S: 39, group S + C: 48, group C:40) and 103 patients with duodenal ulcer (DU) (group S: 35, group S + C: 36, group C:32) were available for statistical analysis. Six to 12 months after healing of GU, the cumulative recurrence prevention rates by Kaplan-Meier method were 89.7----80.3% in group S, 97.6----72.6% in group S + C, 84.5----44.6% in group C. In duodenal ulcer they were 75.9----41.9% in group S, 87.8----47.7% in group S + C, 80.8----40.5% in group C. These results indicate that maintenance therapies of S and S + C are effective and safe for the prevention of gastric ulcer recurrence.
进行了一项双盲、多中心、为期六个月的维持治疗研究，以评估硫糖铝（S）、西咪替丁（C）及其联合用药（S + C）在六个月观察期内预防消化性溃疡复发的疗效和安全性。127例胃溃疡（GU）患者（S组：39例，S + C组：48例，C组：40例）和103例十二指肠溃疡（DU）患者（S组：35例，S + C组：36例，C组：32例）可用于统计分析。GU愈合后6至12个月，采用Kaplan-Meier法计算的累积预防复发率在S组为89.7%至80.3%，S + C组为97.6%至72.6%，C组为84.5%至44.6%。在十二指肠溃疡患者中，这些比率在S组为75.9%至41.9%，S + C组为87.8%至47.7%，C组为80.8%至40.5%。这些结果表明，S和S + C的维持治疗对预防胃溃疡复发有效且安全。
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