Narasimhan Badri Narayanan, Ting Matthew S, Kollmetz Tarek, Horrocks Matthew S, Chalard Anaïs E, Malmström Jenny
Department of Chemical and Materials Engineering, The University of Auckland, Auckland, New Zealand.
MacDiarmid Institute for Advanced Materials and Nanotechnology, Wellington, New Zealand.
Front Bioeng Biotechnol. 2020 Nov 12;8:595978. doi: 10.3389/fbioe.2020.595978. eCollection 2020.
Accurate mechanical characterization of adherent cells and their substrates is important for understanding the influence of mechanical properties on cells themselves. Recent mechanobiology studies outline the importance of mechanical parameters, such as stress relaxation and strain stiffening on the behavior of cells. Numerous techniques exist for probing mechanical properties and it is vital to understand the benefits of each technique and how they relate to each other. This mini review aims to guide the reader through the toolbox of mechanical characterization techniques by presenting well-established and emerging methods currently used to assess mechanical properties of substrates and cells.
准确表征贴壁细胞及其基质的力学特性对于理解力学性能对细胞自身的影响至关重要。最近的力学生物学研究概述了诸如应力松弛和应变硬化等力学参数对细胞行为的重要性。存在多种探测力学性能的技术，了解每种技术的优势以及它们之间的相互关系至关重要。本综述旨在通过介绍目前用于评估基质和细胞力学性能的成熟方法和新兴方法，引导读者了解力学表征技术的工具库。
