Department of Neurology with Stroke Ward, Provincial Specialist Hospital, Bełchatów, Poland.
Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Zabrze, Poland.
Endokrynol Pol. 2020;71(6):504-511. doi: 10.5603/EP.a2020.0082. Epub 2020 Dec 7.
Ischaemic stroke (IS) is a disease that is a common cause of death and one of the most common causes of disability in adults. There is a continuous need to conduct stroke pathogenesis studies. A certain role here can be attributed to adipose-derived hormones. The aim of this paper is to assess the blood concentration for selected adipocytokines: omentin-1, irisin, protein-1 related with C1q/TNF (CTRP1), vaspin and nesfatin-1 in IS patients, and an attempt to define their role as risk factors for ischaemic stroke.
The study included 46 patients with ischaemic stroke (27 females, 19 males, average 67.6 years of age). The control group consisted of 32 patients (16 females, 16 males, average 64.1 years of age) who had never had cerebrovascular diseases.
The concentration of omentin-1 and CTRP1 in the group of stroke patients was higher than in the control group, whereas the concentrations of nesfatin-1 and irisin was significantly lower than in the control group. The vaspin level was similar in both groups of patients. Statistical analysis using logistic regression allows us to find that CTRP1 can be a significant stroke risk factor. A statistically significant positive correlation was found between the concentration of CTRP1 and NIHSS. However, no correlation between the concentration of other adipocytokines under investigation and the severity of ischaemic stroke was found.
From among the adipocytokines under investigation, higher concentrations of omentin-1 and CTRP1 and lower blood concentrations of nesfatin-1, irisin significantly increase the odds of getting to the group of ischaemic patients. It seems that CTRP1 can be an independent predictive factor of IS.
缺血性脑卒中（IS）是一种常见的死亡原因，也是成年人最常见的残疾原因之一。因此需要不断开展脑卒中发病机制的研究。脂肪源性激素在这方面可能起着一定的作用。本文旨在评估缺血性脑卒中患者血液中选定的脂肪细胞因子（网膜素-1、鸢尾素、与 C1q/TNF 相关的蛋白-1（CTRP1）、内脏脂肪素和 nesfatin-1）的浓度，并尝试定义它们作为缺血性脑卒中危险因素的作用。
研究纳入了 46 例缺血性脑卒中患者（27 例女性，19 例男性，平均年龄 67.6 岁）。对照组包括 32 例从未患有脑血管疾病的患者（16 例女性，16 例男性，平均年龄 64.1 岁）。
脑卒中患者组的网膜素-1 和 CTRP1 浓度高于对照组，而 nesfatin-1 和鸢尾素的浓度明显低于对照组。两组患者的内脏脂肪素水平相似。使用逻辑回归的统计学分析允许我们发现 CTRP1 可能是一个显著的脑卒中危险因素。我们发现 CTRP1 浓度与 NIHSS 之间存在显著的正相关。然而，我们没有发现所研究的其他脂肪细胞因子的浓度与缺血性脑卒中的严重程度之间存在相关性。
在所研究的脂肪细胞因子中，较高的网膜素-1 和 CTRP1 浓度以及较低的 nesfatin-1、鸢尾素浓度显著增加了缺血性患者的患病几率。CTRP1 似乎可以成为 IS 的独立预测因子。
