Snow R W, Rowan K M, Greenwood B M
Medical Research Council Laboratories, Fajara, Banjul, The Gambia.
Trans R Soc Trop Med Hyg. 1987;81(4):563-7. doi: 10.1016/0035-9203(87)90408-1.
A trial was undertaken in a rural area of The Gambia to investigate the impact of permethrin-treated bed nets on malaria. Two groups of children, matched for age, sex, and malaria exposure, were followed through the rainy season of 1985 for illness and febrile episodes. One group of 205 children slept under permethrin-treated bed nets (0.5 g/m2); 184 children who slept under placebo-treated nets formed the control group. At the end of the rains the children were examined for splenomegaly and blood samples were taken for determination of packed cell volume (PCV) and parasitaemia. Permethrin treatment of bed nets was well accepted and was without side-effects. Children who slept under treated nets had significantly fewer episodes of clinical malaria than control children. However, at the end of the rains there was no significant difference in the prevalence of splenomegaly or parasitaemia or in the mean PCV between the groups. It is suggested that permethrin treatment of nets may have a greater effect on the duration of probing by mosquitoes for a blood meal than on the number of bites received.
在冈比亚的一个农村地区进行了一项试验，以调查经氯菊酯处理的蚊帐对疟疾的影响。两组年龄、性别和疟疾暴露情况相匹配的儿童在1985年雨季期间被跟踪观察疾病和发热情况。一组205名儿童睡在经氯菊酯处理的蚊帐下（0.5克/平方米）；184名睡在经安慰剂处理蚊帐下的儿童组成对照组。雨季结束时，对儿童进行了脾肿大检查，并采集血样以测定红细胞压积（PCV）和寄生虫血症。经氯菊酯处理的蚊帐很容易被接受，且没有副作用。睡在经处理蚊帐下的儿童临床疟疾发作次数明显少于对照组儿童。然而，雨季结束时，两组之间在脾肿大患病率、寄生虫血症或平均红细胞压积方面没有显著差异。有人认为，用氯菊酯处理蚊帐对蚊子寻找血餐的探测时间可能比对叮咬次数的影响更大。
