血管紧张素转换酶 2、补体系统、激肽释放酶-激肽系统、2 型糖尿病、白细胞介素 6 及其相互作用在复杂的 COVID-19 病理生理学交汇点。
Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads.
机构信息
Independent Researcher, Breda, The Netherlands.
Medical Doctor, General Practice van Dijk, Oisterwijk, The Netherlands.
出版信息
J Renin Angiotensin Aldosterone Syst. 2020 Oct-Dec;21(4):1470320320979097. doi: 10.1177/1470320320979097.
Because of the current COVID-19-pandemic, the world is currently being held hostage in various lockdowns. ACE2 facilitates SARS-CoV-2 cell-entry, and is at the very center of several pathophysiological pathways regarding the RAAS, CS, KKS, T2DM, and IL-6. Their interactions with severe COVID-19 complications (e.g. ARDS and thrombosis), and potential therapeutic targets for pharmacological intervention, will be reviewed.
由于当前的 COVID-19 大流行，世界目前正处于各种封锁之中。ACE2 促进 SARS-CoV-2 细胞进入，并且是 RAAS、CS、KKS、T2DM 和 IL-6 几个病理生理途径的核心。将对它们与严重 COVID-19 并发症（例如 ARDS 和血栓形成）的相互作用以及用于药物干预的潜在治疗靶点进行综述。
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