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血管紧张素转换酶 2、补体系统、激肽释放酶-激肽系统、2 型糖尿病、白细胞介素 6 及其相互作用在复杂的 COVID-19 病理生理学交汇点。

Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads.

机构信息

Independent Researcher, Breda, The Netherlands.

Medical Doctor, General Practice van Dijk, Oisterwijk, The Netherlands.

出版信息

J Renin Angiotensin Aldosterone Syst. 2020 Oct-Dec;21(4):1470320320979097. doi: 10.1177/1470320320979097.

DOI:10.1177/1470320320979097
PMID:33283602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7724427/
Abstract

Because of the current COVID-19-pandemic, the world is currently being held hostage in various lockdowns. ACE2 facilitates SARS-CoV-2 cell-entry, and is at the very center of several pathophysiological pathways regarding the RAAS, CS, KKS, T2DM, and IL-6. Their interactions with severe COVID-19 complications (e.g. ARDS and thrombosis), and potential therapeutic targets for pharmacological intervention, will be reviewed.

摘要

由于当前的 COVID-19 大流行，世界目前正处于各种封锁之中。ACE2 促进 SARS-CoV-2 细胞进入，并且是 RAAS、CS、KKS、T2DM 和 IL-6 几个病理生理途径的核心。将对它们与严重 COVID-19 并发症（例如 ARDS 和血栓形成）的相互作用以及用于药物干预的潜在治疗靶点进行综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/675c98f1e5ef/10.1177_1470320320979097-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/18ee522795c1/10.1177_1470320320979097-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/3b3c63c6c09a/10.1177_1470320320979097-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/9ff435465fd5/10.1177_1470320320979097-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/675c98f1e5ef/10.1177_1470320320979097-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/18ee522795c1/10.1177_1470320320979097-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/3b3c63c6c09a/10.1177_1470320320979097-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/9ff435465fd5/10.1177_1470320320979097-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/675c98f1e5ef/10.1177_1470320320979097-fig4.jpg

相似文献

[1]
Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads.

J Renin Angiotensin Aldosterone Syst. 2020

[2]
Role of the Renin-Angiotensin-Aldosterone and Kinin-Kallikrein Systems in the Cardiovascular Complications of COVID-19 and Long COVID.

Int J Mol Sci. 2021-7-31

[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
The home-based breathing and chest mobility exercise improves cardiorespiratory functional capacity in long COVID with cardiovascular comorbidities: a randomized study.

BMC Cardiovasc Disord. 2024-10-18

[2]
Association of clinical characteristics, antidiabetic and cardiovascular agents with diabetes mellitus and COVID-19: a 7-month follow-up cohort study.

J Diabetes Metab Disord. 2021-11-8

[3]
Resolution of Disseminated Intravascular Coagulation in a Patient with COVID-19 and Associated Sepsis-Induced Neutropenia.

Medicina (Kaunas). 2021-1-24

本文引用的文献

[1]
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.

Sci Adv. 2020-7-24

[2]
Interleukin-6 in Covid-19: A systematic review and meta-analysis.

Rev Med Virol. 2020-8-26

[3]
Relationship Between the ABO Blood Group and the Coronavirus Disease 2019 (COVID-19) Susceptibility.

Clin Infect Dis. 2021-7-15

[4]
Methylation Pathways and SARS-CoV-2 Lung Infiltration and Cell Membrane-Virus Fusion Are Both Subject to Epigenetics.

Front Cell Infect Microbiol. 2020-5-26

[5]
Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation.

Aging Cell. 2020-6-19

[6]
Acquired angioedema induced by angiotensin-converting enzyme inhibitors - experience of a hospital-based allergy center.

Exp Ther Med. 2020-7

[7]
Negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients.

Diabetes Metab. 2020-5-21

[8]
Downregulation of ACE2 induces overstimulation of the renin-angiotensin system in COVID-19: should we block the renin-angiotensin system?

Hypertens Res. 2020-8

[9]
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?

Int J Mol Sci. 2020-5-14

[10]
SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the 'culprit lesion' of ARDS onset? What is there besides Tocilizumab? SGP130Fc.

Cytokine X. 2020-6

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