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血管紧张素转换酶 2、补体系统、激肽释放酶-激肽系统、2 型糖尿病、白细胞介素 6 及其相互作用在复杂的 COVID-19 病理生理学交汇点。

Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads.

机构信息

Independent Researcher, Breda, The Netherlands.

Medical Doctor, General Practice van Dijk, Oisterwijk, The Netherlands.

出版信息

J Renin Angiotensin Aldosterone Syst. 2020 Oct-Dec;21(4):1470320320979097. doi: 10.1177/1470320320979097.

DOI:10.1177/1470320320979097
PMID:33283602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7724427/
Abstract

Because of the current COVID-19-pandemic, the world is currently being held hostage in various lockdowns. ACE2 facilitates SARS-CoV-2 cell-entry, and is at the very center of several pathophysiological pathways regarding the RAAS, CS, KKS, T2DM, and IL-6. Their interactions with severe COVID-19 complications (e.g. ARDS and thrombosis), and potential therapeutic targets for pharmacological intervention, will be reviewed.

摘要

由于当前的 COVID-19 大流行，世界目前正处于各种封锁之中。ACE2 促进 SARS-CoV-2 细胞进入，并且是 RAAS、CS、KKS、T2DM 和 IL-6 几个病理生理途径的核心。将对它们与严重 COVID-19 并发症（例如 ARDS 和血栓形成）的相互作用以及用于药物干预的潜在治疗靶点进行综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/675c98f1e5ef/10.1177_1470320320979097-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/18ee522795c1/10.1177_1470320320979097-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/3b3c63c6c09a/10.1177_1470320320979097-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/9ff435465fd5/10.1177_1470320320979097-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/675c98f1e5ef/10.1177_1470320320979097-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/18ee522795c1/10.1177_1470320320979097-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/3b3c63c6c09a/10.1177_1470320320979097-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/9ff435465fd5/10.1177_1470320320979097-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5563/7724427/675c98f1e5ef/10.1177_1470320320979097-fig4.jpg

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2
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Rev Med Virol. 2020 Nov;30(6):1-9. doi: 10.1002/rmv.2141. Epub 2020 Aug 26.
3
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ABO 血型与 2019 年冠状病毒病（COVID-19）易感性的关系。
Clin Infect Dis. 2021 Jul 15;73(2):328-331. doi: 10.1093/cid/ciaa1150.
4
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