Gao Yu, Fajrial Apresio K, Yang Tao, Ding Xiaoyun
Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO 80309, USA.
Biomater Sci. 2021 Mar 10;9(5):1574-1582. doi: 10.1039/d0bm01269f.
A surface acoustic wave (SAW) is a sound wave travelling on the surface of an elastic material. SAW offers a robust control of the acoustic energy leading to an unparalleled versatility. As an actuator, SAW can exert acoustic forces on particles and fluids thus enabling dexterous micro/nanoscale manipulations. As a sensor, SAW has a unique sensing capability upon changes in the environment. On-chip SAW technology, in which SAW is integrated with modern lab-on-a-chip (LOC), has drawn a lot of attention in recent years and found various exciting applications in micro/nanosystems. In particular, its well-known biocompatibility provides on-chip SAW technology as an exceptional platform for biomaterials research at the small-scale. In this minireview, we highlighted recent advances of on-chip SAW technology for biomaterials manipulation and characterization with a focus on cell-based (e.g. single-cell and multicellular) biomaterials. We also discussed and shared our perspective on future directions for this emerging research field.
表面声波（SAW）是一种在弹性材料表面传播的声波。SAW能够对声能进行强大的控制，从而具备无与伦比的多功能性。作为一种致动器，SAW可以对颗粒和流体施加声力，从而实现灵活的微/纳米级操作。作为一种传感器，SAW在环境变化时具有独特的传感能力。片上SAW技术将SAW与现代芯片实验室（LOC）集成在一起，近年来备受关注，并在微/纳米系统中发现了各种令人兴奋的应用。特别是，其众所周知的生物相容性为片上SAW技术提供了一个用于小规模生物材料研究的卓越平台。在本综述中，我们重点介绍了片上SAW技术在生物材料操作和表征方面的最新进展，重点关注基于细胞的（如单细胞和多细胞）生物材料。我们还讨论并分享了我们对这个新兴研究领域未来方向的看法。
