Hagiwara Kei, Harimoto Norifumi, Araki Kenichiro, Watanabe Akira, Kubo Norio, Nakazawa Seshiru, Yajima Toshiki, Uchida Nobuyuki, Shirabe Ken
Gunma University Graduate School of Medicine, Hepatobiliary and Pancreatic Surgery, 3-39-22 Showa-machi, Maebashi, Japan.
Department of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Surg Case Rep. 2020 Dec 7;6(1):309. doi: 10.1186/s40792-020-01029-y.
The efficacy of resection of pancreatic cancer metastases has not been established. We here report two patients with long-term survival after resection of lung and liver metastases.
The first patient underwent distal pancreatectomy for pancreatic cancer. One year later, she underwent partial hepatectomy for a single liver metastasis. She subsequently underwent pulmonary resections 7, 7.5, 9, and 10 years later for pulmonary metastases from pancreatic cancer. Thus, this patient underwent five surgeries for metastases, one for a liver metastasis and four for lung metastases. All of the tumors were pathologically diagnosed as metastatic pancreatic cancer. She is currently alive without new recurrence 10 years after the initial diagnosis. The second patient underwent pancreaticoduodenectomy for pancreatic cancer. Four years later, she underwent a thoracoscopic partial resection for lung metastasis. The tumor was similar to the pancreatic cancer on pathological examination. She is currently alive without new recurrences 6 years after the initial diagnosis.
Long-term survival can be achieved in some patients with pancreatic cancer by resection of metachronous liver or lung metastases.
胰腺癌转移灶切除的疗效尚未确定。我们在此报告两例在切除肺和肝转移灶后长期存活的患者。
首例患者因胰腺癌接受了胰体尾切除术。一年后，她因单个肝转移灶接受了肝部分切除术。随后，她在7年、7.5年、9年和10年后因胰腺癌肺转移接受了肺切除术。因此，该患者因转移灶接受了五次手术，一次是肝转移灶手术，四次是肺转移灶手术。所有肿瘤经病理诊断均为转移性胰腺癌。她目前在初次诊断后10年仍存活且无新的复发。第二例患者因胰腺癌接受了胰十二指肠切除术。四年后，她因肺转移接受了胸腔镜下部分切除术。病理检查显示肿瘤与胰腺癌相似。她目前在初次诊断后6年仍存活且无新的复发。
部分胰腺癌患者通过切除异时性肝或肺转移灶可实现长期存活。
