Center for Translational Behavioral Science, Florida State University, Tallahassee, FL, USA.
Anschutz Medical Campus, University of Colorado, Denver, CO, USA.
Aging Ment Health. 2021 Dec;25(12):2272-2278. doi: 10.1080/13607863.2020.1855626. Epub 2020 Dec 7.
Depression, pain, and fatigue are common and bothersome symptoms in heart failure, a serious illness in older adults. Understanding longitudinal pathways among depression, pain, and fatigue in heart failure could inform treatment and improve quality of life.
We completed secondary, longitudinal data analyses of a sample of older adults with heart failure (baseline = 317). Bootstrapped mediation was used to examine two longitudinal models of pain and depression, with fatigue at 6-months as the mediator. The outcome variables were 12-month pain and depression.
Depressive symptoms were associated with new onset of pain symptoms; however, this association was mediated by fatigue. Pain was not associated with new depression or fatigue symptoms in this sample.
In patients with heart-failure, worsening pain symptoms appear to be directly related to levels of depression and fatigue. These findings demonstrate that depression and fatigue may be key to reducing pain symptoms in this population.
在老年人中，心力衰竭是一种严重的疾病，其常见且令人困扰的症状包括抑郁、疼痛和疲劳。了解心力衰竭中抑郁、疼痛和疲劳之间的纵向途径可以为治疗提供信息并改善生活质量。
我们对心力衰竭的老年患者样本（基线 = 317）进行了二次纵向数据分析。使用bootstrap 中介分析检验了疼痛和抑郁的两个纵向模型，以 6 个月时的疲劳为中介。因变量是 12 个月时的疼痛和抑郁。
抑郁症状与新出现的疼痛症状相关；然而，这种关联是由疲劳介导的。在该样本中，疼痛与新的抑郁或疲劳症状无关。
在心力衰竭患者中，疼痛症状的恶化似乎与抑郁和疲劳水平直接相关。这些发现表明，在该人群中，抑郁和疲劳可能是减轻疼痛症状的关键。
