Universität Witten/Herdecke, Alfred-Herrhausen-Strasse 50, 58448, Witten, Germany.
BMC Public Health. 2020 Dec 7;20(1):1880. doi: 10.1186/s12889-020-09970-1.
Findings on the association between exposure to secondhand smoke (SHS) and depression are contradictory. Comparability of existing research is limited due to varied methods and measures. This study examines the potential association between exposure to SHS and depression and a potential moderation by sex using representative data from Germany.
For our study, we used data from the German Health Update (GEDA) 2014/2015 on n = 10,274 never-smokers. We calculated a logistic regression model with an interaction term for potential sex-exposure interactions. We used the self-reported duration of exposure to predict current depression of any type as defined by the Patient Health Questionnaire PHQ-8 (score ≥ 10), accounting for a large number of confounders.
In our sample, prevalence of depression was 8.8% in women and 5.3% in men. 90.4% were never or almost never exposed to SHS, while 7.1% were exposed < 1 h per day and around 2.5% reported being exposed for ≥1 h per day. While SHS exposure for < 1 h per day was not associated with current depression (OR = 1.54; 95%-CI: 0.93-1.61), SHS exposure for at least 1 h per day was associated with increased odds for current depression (OR = 1.59; 95%-CI: 1.08-2.35). No sex-specific differences were found.
Higher levels of SHS exposure are associated with current depression, although the nature and direction of the association are still unclear. We identified no differences in the association between men and women. More studies, particularly using longitudinal data, are needed to determine the nature of the association.
二手烟（SHS）暴露与抑郁之间的关联结果存在矛盾。由于方法和测量手段的不同，现有研究的可比性有限。本研究使用德国的代表性数据，检验 SHS 暴露与抑郁之间的潜在关联，以及性别可能产生的调节作用。
我们使用了 2014/2015 年德国健康更新调查（GEDA）中 n=10274 名从不吸烟的人的数据。我们计算了一个逻辑回归模型，其中包含了一个潜在的性别-暴露交互作用的交互项。我们使用自我报告的暴露持续时间来预测任何类型的当前抑郁，其定义为患者健康问卷 PHQ-8（得分≥10），同时考虑了大量混杂因素。
在我们的样本中，女性的抑郁患病率为 8.8%，男性为 5.3%。90.4%的人从未或几乎从未接触过 SHS，7.1%的人每天接触 SHS 的时间<1 小时，约 2.5%的人每天接触 SHS 的时间≥1 小时。每天接触 SHS 的时间<1 小时与当前抑郁无关（OR=1.54；95%-CI：0.93-1.61），而每天接触 SHS 的时间至少 1 小时与当前抑郁的几率增加相关（OR=1.59；95%-CI：1.08-2.35）。未发现性别特异性差异。
较高水平的 SHS 暴露与当前抑郁相关，尽管关联的性质和方向仍不清楚。我们没有发现男性和女性之间的关联存在差异。需要更多的研究，特别是使用纵向数据，来确定这种关联的性质。
