Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
Psychosom Med. 2010 Jan;72(1):68-72. doi: 10.1097/PSY.0b013e3181c6c8b5. Epub 2009 Nov 30.
To evaluate the association between secondhand smoke (SHS) exposure and depression. Tobacco smoking and depression are strongly associated, but the possible effects of SHS have not been evaluated.
The 2005 to 2006 National Health and Nutrition Examination Survey (NHANES) is a cross-sectional sample of the noninstitutionalized civilian U.S. population. SHS exposure was measured in adults aged > or =20 years by serum cotinine and depressive symptoms by the Patient Health Questionnaire. Zero-inflated Poisson regression analyses were completed with adjustment for survey design and potential confounders.
Serum cotinine-documented SHS exposure was positively associated with depressive symptoms in never-smokers, even after adjustment for age, race/ethnicity, gender, education, alcohol consumption, and medical comorbidities. The association between SHS exposure and depressive symptoms did not vary by gender, nor was there any association between SHS smoke exposure and depressive symptoms in former smokers.
Findings from the present study suggest that SHS exposure is positively associated with depressive symptoms in never-smokers and highlight the need for further research to establish the mechanisms of association.
评估二手烟（SHS）暴露与抑郁之间的关联。烟草吸烟与抑郁密切相关，但尚未评估 SHS 的可能影响。
2005 年至 2006 年全国健康和营养调查（NHANES）是对非住院的美国平民人口的横断面抽样调查。通过血清可替宁和患者健康问卷评估>或=20 岁成年人的 SHS 暴露情况和抑郁症状。通过调查设计和潜在混杂因素的调整，完成了零膨胀泊松回归分析。
血清可替宁证实的 SHS 暴露与从不吸烟者的抑郁症状呈正相关，即使在调整了年龄、种族/民族、性别、教育、饮酒和合并症后也是如此。SHS 暴露与抑郁症状之间的关联不受性别影响，也没有发现 SHS 烟雾暴露与曾经吸烟者的抑郁症状之间的任何关联。
本研究结果表明，SHS 暴露与从不吸烟者的抑郁症状呈正相关，突出了需要进一步研究以确定关联机制。
