CRISPR/Cas9 从实验室到临床：应用前临床医生需要了解什么？
CRISPR/Cas9 from bench to bedside: what clinicians need to know before application?
机构信息
Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
出版信息
Mil Med Res. 2020 Dec 8;7(1):61. doi: 10.1186/s40779-020-00292-2.
Abstract
In October 2020, Dr. Emmanuelle Charpentier and Dr. Jennifer Doudna won the Nobel Prize in Chemistry for their pioneering work in precise genome editing using the CRISPR technology. Although CRISPR technology has developed rapidly in the last decade, there are still many uncertainties before eventual use in clinical settings. In this mini review, we summarize the current efforts in addressing the limitations of CRISPR technology and future directions.
摘要
2020 年 10 月，埃玛纽埃尔·卡彭蒂耶博士和詹妮弗·杜德娜博士因使用 CRISPR 技术进行精确基因组编辑的开创性工作而获得诺贝尔化学奖。尽管 CRISPR 技术在过去十年中发展迅速，但在最终用于临床环境之前，仍存在许多不确定性。在这篇迷你综述中，我们总结了目前解决 CRISPR 技术局限性的努力和未来的方向。
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