[肠道杆菌中抗生素耐药性的遗传决定因素]
[Genetic determinants of antibiotic resistance in enterobacteria].
作者信息
Anisimova L A, Viatkina G G, Korotiaev A I, Boronin A M
出版信息
Mol Gen Mikrobiol Virusol. 1987 Dec(12):40-5.
Antibiotic resistance of enterobacterial strains from population isolated in Krasnodar region is rather often controlled by the "plasmid" genes. The conclusion is based on using the colony hybridization with [32P]-DNA fragments of plasmids, carrying the genetic determinants of antibiotic resistance, as a method for antibiotic resistance, genes screening. Kanamycin resistance in the majority of strains is coded by APH (3') II gene, streptomycin resistance by APH (3") gene, chloramphenicol resistance by CATI, sulphonilamide resistance by DHPS type II gene. Tetracycline resistance of the studied enterobacterial strains is not connected with the widespread genetic determinants of a new class tetracycline resistance.
克拉斯诺达尔地区人群分离出的肠杆菌菌株的抗生素耐药性通常由“质粒”基因控制。该结论基于使用与携带抗生素耐药性遗传决定因素的质粒[32P]-DNA片段进行菌落杂交，作为筛选抗生素耐药性基因的方法。大多数菌株中的卡那霉素耐药性由APH(3')II基因编码，链霉素耐药性由APH(3")基因编码，氯霉素耐药性由CATI编码，磺胺耐药性由II型DHPS基因编码。所研究的肠杆菌菌株的四环素耐药性与新一类四环素耐药性的广泛遗传决定因素无关。
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