Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Aging (Albany NY). 2020 Dec 3;13(1):376-388. doi: 10.18632/aging.202142.
To date, few reports have investigated the genetic alterations and clinicopathological features in gastric cancer (GC) according to sex. In total, 2673 GC patients receiving curative surgery were enrolled. Among the 2673 GC patients, 1979 (74.0%) patients were male. After propensity-score matching, 846 patients were enrolled for the analysis, including 423 males and 423 females. There was no significant difference in the clinicopathological features between the sexes. Regarding the initial recurrence pattern, the males were more likely to develop tumor recurrence and liver metastasis than the females, especially in stage III GC. Regarding the molecular analysis, the males had higher expression than the females, especially in stage III GC. In addition, the patients aged ≥ 65 years had higher expression than the patients younger than 65 years. The multivariate analysis demonstrated that sex was among the independent prognostic factors affecting overall survival (OS) and disease-free survival (DFS). Among the patients with liver metastases, expression was more common among the aged male patients. The males were associated with more tumor recurrence and higher expression than the females, especially in stage III GC. For GC patients with liver metastases, testing is recommended, especially among aged male patients.
迄今为止，鲜有研究根据性别调查胃癌（GC）的遗传改变和临床病理特征。共纳入 2673 例行根治性手术的 GC 患者。在这 2673 例 GC 患者中，1979 例（74.0%）为男性。经过倾向评分匹配后，共纳入 846 例患者进行分析，其中男性 423 例，女性 423 例。两组间的临床病理特征无显著差异。在初始复发模式方面，男性比女性更容易发生肿瘤复发和肝转移，尤其是在 III 期 GC 中。在分子分析方面，男性的表达水平高于女性，尤其是在 III 期 GC 中。此外，年龄≥65 岁的患者较年龄＜65 岁的患者有更高的表达水平。多因素分析表明，性别是影响总生存（OS）和无病生存（DFS）的独立预后因素之一。在发生肝转移的患者中，年龄较大的男性患者中更常见 表达。男性比女性更易发生肿瘤复发和更高的表达水平，尤其是在 III 期 GC 中。对于发生肝转移的 GC 患者，建议进行 检测，尤其是在年龄较大的男性患者中。
