Department of Chemistry, University of Georgia, Athens, GA 30602, USA.
Department of Molecular & Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
Nanomedicine (Lond). 2019 Mar;14(5):627-648. doi: 10.2217/nnm-2018-0147. Epub 2019 Feb 26.
As effective tools for public health, vaccines prevent disease by priming the body's adaptive and innate immune responses against an infection. Due to advances in understanding cancers and their relationship with the immune system, there is a growing interest in priming host immune defenses for a targeted and complete antitumor response. Nanoparticle systems have shown to be promising tools for effective antigen delivery as vaccines and/or for potentiating immune response as adjuvants. Here, we highlight relevant physiological processes involved in vaccine delivery, review recent advances in the use of nanoparticle systems for vaccines and discuss pertinent challenges to viably translate nanoparticle-based vaccines and adjuvants for public use.
作为公共卫生的有效工具，疫苗通过启动身体对感染的适应性和先天免疫反应来预防疾病。由于对癌症及其与免疫系统的关系的理解不断深入，人们越来越感兴趣的是启动宿主免疫防御，以实现针对肿瘤的靶向和完全的应答。纳米颗粒系统已被证明是有效的抗原递呈的有前途的工具，可用作疫苗和/或佐剂来增强免疫反应。在这里，我们重点介绍疫苗递送中涉及的相关生理过程，综述纳米颗粒系统在疫苗中的应用的最新进展，并讨论将基于纳米颗粒的疫苗和佐剂有效地转化为公众使用所面临的相关挑战。
