Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Netherlands Institute for Neuroscience, Royal Academy of Sciences (KNAW), Amsterdam, The Netherlands.
Nat Neurosci. 2021 Feb;24(2):160-167. doi: 10.1038/s41593-020-00754-9. Epub 2020 Dec 7.
The past several years have brought revelations and paradigm shifts in research on the cerebellum. Historically viewed as a simple sensorimotor controller with homogeneous architecture, the cerebellum is increasingly implicated in cognitive functions. It possesses an impressive diversity of molecular, cellular and circuit mechanisms, embedded in a dynamic, recurrent circuit architecture. Recent insights about the diversity and dynamism of the cerebellum provide a roadmap for the next decade of cerebellar research, challenging some old concepts, reinvigorating others and defining major new research directions.
过去几年里,人们对小脑的研究有了新的发现和范式转变。小脑在历史上被视为具有同质结构的简单感觉运动控制器,而现在它越来越被认为与认知功能有关。小脑拥有令人印象深刻的分子、细胞和电路机制多样性,嵌入在动态、递归的电路结构中。最近对小脑多样性和动态性的了解为未来十年的小脑研究提供了路线图,挑战了一些旧概念,重振了其他概念,并确定了主要的新研究方向。