Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Int J Numer Method Biomed Eng. 2021 Mar;37(3):e3425. doi: 10.1002/cnm.3425. Epub 2020 Dec 13.
Stiffness is an important parameter to evaluate the condition of trabecular bone in biomechanical and clinical research. Microstructural parameters are commonly used to evaluate stiffness, but the accuracy needs to be improved. In this study, the electrical conductance of trabecular bone was calculated based on an idealized condition: trabeculae were electrically conductive and isotropy, other constituents in the trabecular bone were not considered in the simulation. The idealized conductance was calculated to evaluate the stiffness of trabecular bone, and the accuracy was compared with microstructural parameters. Twenty-one cubic trabecular cubes (5 × 5 × 5 mm ) from three femoral heads were investigated. Microstructural parameters were measured through Micro-CT scanning. Nominal elastic modulus (E) and idealized conductance (G) of trabecular cubes were measured through micro-finite element analysis. Bone volume fraction (BV/TV) is the major microstructural parameter that determine the stiffness of trabecular bone. The correlation coefficient between BV/TV and E along three directions were 0.815 (X-axis), 0.729 (Y-axis) and 0.914 (Z-axis). The correlation between G and E were stronger (X-axis: r = 0.986, Y-axis: r = 0.986, Z-axis: r = 0.991). A regression model combining different microstructural parameters was built to evaluate stiffness, but the correlation between them were not significantly improved (X-axis: r = 0.831, Y-axis: r = 0.807, Z-axis: r = 0.905). Compared with microstructural parameters, idealized conductance was a better parameter to evaluate stiffness of trabecular bone.
刚性是评估生物力学和临床研究中小梁骨状况的一个重要参数。微结构参数通常用于评估刚性，但准确性需要提高。在这项研究中，基于理想化条件计算了小梁骨的电导率：小梁是导电且各向同性的，模拟中不考虑小梁骨中的其他成分。计算理想电导率以评估小梁骨的刚性，并将其与微结构参数进行比较。从三个股骨头中研究了 21 个立方小梁骨（5×5×5mm）。通过 Micro-CT 扫描测量微结构参数。通过微有限元分析测量小梁骨的名义弹性模量（E）和理想电导（G）。骨体积分数（BV/TV）是决定小梁骨刚性的主要微结构参数。BV/TV 与三个方向上的 E 之间的相关系数分别为 0.815（X 轴）、0.729（Y 轴）和 0.914（Z 轴）。G 与 E 之间的相关性更强（X 轴：r = 0.986，Y 轴：r = 0.986，Z 轴：r = 0.991）。建立了一个结合不同微结构参数的回归模型来评估刚性，但它们之间的相关性没有显著提高（X 轴：r = 0.831，Y 轴：r = 0.807，Z 轴：r = 0.905）。与微结构参数相比，理想电导率是评估小梁骨刚性的更好参数。
