• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

预测与世界贸易中心相关肺损伤治疗的因素：一项纵向队列研究。

Factors Predicting Treatment of World Trade Center-Related Lung Injury: A Longitudinal Cohort Study.

机构信息

Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium.

Pulmonary, Critical Care and Sleep Medicine Division, Department of Medicine and Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA.

出版信息

Int J Environ Res Public Health. 2020 Dec 4;17(23):9056. doi: 10.3390/ijerph17239056.

DOI:10.3390/ijerph17239056
PMID:33291671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7730939/
Abstract

The factors that predict treatment of lung injury in occupational cohorts are poorly defined. We aimed to identify patient characteristics associated with initiation of treatment with inhaled corticosteroid/long-acting beta-agonist (ICS/LABA) >2 years among World Trade Center (WTC)-exposed firefighters. The study population included 8530 WTC-exposed firefighters. Multivariable logistic regression assessed the association of patient characteristics with ICS/LABA treatment for >2 years over two-year intervals from 11 September 2001-10 September 2017. Cox proportional hazards models measured the association of high probability of ICS/LABA initiation with actual ICS/LABA initiation in subsequent intervals. Between 11 September 2001-1 July 2018, 1629/8530 (19.1%) firefighters initiated ICS/LABA treatment for >2 years. Forced Expiratory Volume in 1 s (FEV), wheeze, and dyspnea were consistently and independently associated with ICS/LABA treatment. High-intensity WTC exposure was associated with ICS/LABA between 11 September 2001-10 September 2003. The 10th percentile of risk for ICS/LABA between 11 September 2005-10 Septmeber 2007 was associated with a 3.32-fold increased hazard of actual ICS/LABA initiation in the subsequent 4 years. In firefighters with WTC exposure, FEV, wheeze, and dyspnea were independently associated with prolonged ICS/LABA treatment. A high risk for treatment was identifiable from routine monitoring exam results years before treatment initiation.

摘要

预测职业人群肺损伤治疗的因素尚未明确。本研究旨在确定与 World Trade Center（WTC）暴露消防员吸入性皮质类固醇/长效β激动剂（ICS/LABA）治疗>2 年相关的患者特征。研究人群包括 8530 名 WTC 暴露消防员。多变量逻辑回归评估了患者特征与 2001 年 9 月 11 日至 2017 年 9 月 10 日期间每两年 ICS/LABA 治疗>2 年的相关性。Cox 比例风险模型衡量了 ICS/LABA 起始概率高与随后各时间段实际 ICS/LABA 起始的相关性。2001 年 9 月 11 日至 2018 年 7 月 1 日期间，1629/8530（19.1%）名消防员 ICS/LABA 治疗>2 年。用力呼气 1 秒（FEV1）、喘息和呼吸困难与 ICS/LABA 治疗始终存在且独立相关。高强度 WTC 暴露与 2001 年 9 月 11 日至 2003 年 9 月 10 日期间的 ICS/LABA 治疗相关。2005 年 9 月 11 日至 2007 年 9 月 10 日期间 ICS/LABA 风险的第 10 个百分位数与随后 4 年实际 ICS/LABA 起始的风险增加 3.32 倍相关。在有 WTC 暴露的消防员中，FEV1、喘息和呼吸困难与 ICS/LABA 治疗时间延长独立相关。在开始治疗前数年，通过常规监测检查结果即可识别出高治疗风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11e5/7730939/3c2df020820a/ijerph-17-09056-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11e5/7730939/cd8d1b3b04ec/ijerph-17-09056-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11e5/7730939/995ef98f1af9/ijerph-17-09056-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11e5/7730939/3c2df020820a/ijerph-17-09056-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11e5/7730939/cd8d1b3b04ec/ijerph-17-09056-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11e5/7730939/995ef98f1af9/ijerph-17-09056-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11e5/7730939/3c2df020820a/ijerph-17-09056-g003a.jpg

相似文献

1
Factors Predicting Treatment of World Trade Center-Related Lung Injury: A Longitudinal Cohort Study.预测与世界贸易中心相关肺损伤治疗的因素：一项纵向队列研究。
Int J Environ Res Public Health. 2020 Dec 4;17(23):9056. doi: 10.3390/ijerph17239056.
2
Lung function decline before and after treatment of World Trade Center associated obstructive airways disease with inhaled corticosteroids and long-acting beta agonists.世贸中心相关阻塞性气道疾病经吸入皮质类固醇和长效β激动剂治疗前后的肺功能下降。
Am J Ind Med. 2021 Oct;64(10):853-860. doi: 10.1002/ajim.23272. Epub 2021 Jul 13.
3
Effects of inhaled corticosteroids /long-acting agonists in a single inhaler versus inhaled corticosteroids alone on all-cause mortality, pneumonia, and fracture in chronic obstructive pulmonary disease: A nationwide cohort study 2002-2013.吸入皮质类固醇/长效激动剂单药与吸入皮质类固醇单独治疗在慢性阻塞性肺疾病患者全因死亡率、肺炎和骨折中的影响：2002-2013 年全国队列研究。
Respir Med. 2017 Sep;130:75-84. doi: 10.1016/j.rmed.2017.07.012. Epub 2017 Jul 19.
4
Efficacy of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Versus Other Inhaled Corticosteroid/Long-Acting Muscarinic Antagonist/Long-Acting β-Agonist (ICS/LAMA/LABA) Triple Combinations in COPD: A Systematic Literature Review and Network Meta-analysis.布地奈德/格隆溴铵/富马酸福莫特罗干粉吸入剂（BGF MDI）对比其他吸入性皮质类固醇/长效毒蕈碱拮抗剂/长效β激动剂（ICS/LAMA/LABA）三联复方制剂治疗 COPD 的疗效：系统文献评价和网络荟萃分析。
Adv Ther. 2020 Jun;37(6):2956-2975. doi: 10.1007/s12325-020-01311-3. Epub 2020 Apr 25.
5
Comparative Effectiveness of Long-Acting Beta -Agonist Combined with a Long-Acting Muscarinic Antagonist or Inhaled Corticosteroid in Chronic Obstructive Pulmonary Disease.长效β受体激动剂联合长效毒蕈碱拮抗剂或吸入性糖皮质激素治疗慢性阻塞性肺疾病的比较疗效
Pharmacotherapy. 2017 Apr;37(4):447-455. doi: 10.1002/phar.1913.
6
Low serum IgA and airway injury in World Trade Center-exposed firefighters: a 17-year longitudinal study.世贸中心暴露消防员的低血清 IgA 和气道损伤：一项 17 年的纵向研究。
Thorax. 2019 Dec;74(12):1182-1184. doi: 10.1136/thoraxjnl-2019-213715. Epub 2019 Oct 14.
7
Blood Leukocyte Concentrations, FEV Decline, and Airflow Limitation. A 15-Year Longitudinal Study of World Trade Center-exposed Firefighters.血液白细胞浓度、FEV 下降和气流受限。暴露于世界贸易中心的消防员的 15 年纵向研究。
Ann Am Thorac Soc. 2018 Feb;15(2):173-183. doi: 10.1513/AnnalsATS.201703-276OC.
8
Impact of long-acting bronchodilators and exposure to inhaled corticosteroids on mortality in COPD: a real-life retrospective cohort study.长效支气管扩张剂及吸入性糖皮质激素暴露对慢性阻塞性肺疾病死亡率的影响：一项基于现实生活的回顾性队列研究
Lung. 2014 Oct;192(5):649-52. doi: 10.1007/s00408-014-9611-8. Epub 2014 Jun 22.
9
Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters.心血管生物标志物可预测接触世贸中心粉尘的消防员肺损伤易感性。
Eur Respir J. 2013 May;41(5):1023-30. doi: 10.1183/09031936.00077012. Epub 2012 Aug 16.
10
The effect of umeclidinium added to inhaled corticosteroid/long-acting β2-agonist in patients with symptomatic COPD: a randomised, double-blind, parallel-group study.在有症状的 COPD 患者中，乌美溴铵联合吸入性皮质类固醇/长效β2-激动剂的疗效：一项随机、双盲、平行分组研究。
NPJ Prim Care Respir Med. 2016 Jun 23;26:16031. doi: 10.1038/npjpcrm.2016.31.

引用本文的文献

1
Health effects following exposure to dust from the World Trade Center disaster: An update.接触世界贸易中心灾难尘埃后的健康影响：最新进展。
Life Sci. 2022 Jan 15;289:120147. doi: 10.1016/j.lfs.2021.120147. Epub 2021 Nov 14.
2
Lung function decline before and after treatment of World Trade Center associated obstructive airways disease with inhaled corticosteroids and long-acting beta agonists.世贸中心相关阻塞性气道疾病经吸入皮质类固醇和长效β激动剂治疗前后的肺功能下降。
Am J Ind Med. 2021 Oct;64(10):853-860. doi: 10.1002/ajim.23272. Epub 2021 Jul 13.
3
9/11 Health Update.

本文引用的文献

1
Detecting asthma exacerbations using daily home monitoring and machine learning.利用日常家庭监测和机器学习检测哮喘加重。
J Asthma. 2021 Nov;58(11):1518-1527. doi: 10.1080/02770903.2020.1802746. Epub 2020 Aug 14.
2
Persistence and Adherence to ICS/LABA Drugs in UK Patients with Asthma: A Retrospective New-User Cohort Study.英国哮喘患者对 ICS/LABA 药物的坚持和依从性：一项回顾性新使用者队列研究。
Adv Ther. 2020 Jun;37(6):2916-2931. doi: 10.1007/s12325-020-01344-8. Epub 2020 May 2.
3
Dyspnea and Inhaled Corticosteroid and Long-acting β-Agonist Therapy in an Occupational Cohort: A Longitudinal Study.
9·11 健康状况更新。
Int J Environ Res Public Health. 2021 Jun 12;18(12):6383. doi: 10.3390/ijerph18126383.
职业队列中呼吸困难与吸入性糖皮质激素及长效β受体激动剂治疗：一项纵向研究
Ann Am Thorac Soc. 2020 Jun;17(6):770-773. doi: 10.1513/AnnalsATS.201910-794RL.
4
Predictors of Asthma/COPD Overlap in FDNY Firefighters With World Trade Center Dust Exposure: A Longitudinal Study.有世界贸易中心粉尘暴露史的 FDNY 消防员哮喘/COPD 重叠的预测因素：一项纵向研究。
Chest. 2018 Dec;154(6):1301-1310. doi: 10.1016/j.chest.2018.07.002. Epub 2018 Jul 17.
5
Blood Leukocyte Concentrations, FEV Decline, and Airflow Limitation. A 15-Year Longitudinal Study of World Trade Center-exposed Firefighters.血液白细胞浓度、FEV 下降和气流受限。暴露于世界贸易中心的消防员的 15 年纵向研究。
Ann Am Thorac Soc. 2018 Feb;15(2):173-183. doi: 10.1513/AnnalsATS.201703-276OC.
6
Wearable technology: role in respiratory health and disease.可穿戴技术：在呼吸健康与疾病中的作用。
Breathe (Sheff). 2017 Jun;13(2):e27-e36. doi: 10.1183/20734735.008417.
7
The role of tele-medicine in patients with respiratory diseases.远程医疗在呼吸系统疾病患者中的作用。
Expert Rev Respir Med. 2017 Nov;11(11):893-900. doi: 10.1080/17476348.2017.1383898. Epub 2017 Sep 27.
8
FDNY and 9/11: Clinical services and health outcomes in World Trade Center-exposed firefighters and EMS workers from 2001 to 2016.纽约市消防局与9·11事件：2001年至2016年世贸中心暴露消防员及紧急医疗服务人员的临床服务与健康状况
Am J Ind Med. 2016 Sep;59(9):695-708. doi: 10.1002/ajim.22631. Epub 2016 Jul 18.
9
A summary of the new GINA strategy: a roadmap to asthma control.新全球哮喘防治创议（GINA）策略总结：哮喘控制路线图
Eur Respir J. 2015 Sep;46(3):622-39. doi: 10.1183/13993003.00853-2015. Epub 2015 Jul 23.
10
The Duration of an Exposure Response Gradient between Incident Obstructive Airways Disease and Work at the World Trade Center Site: 2001-2011.2001年至2011年世贸中心遗址事件性阻塞性气道疾病与工作之间暴露反应梯度的持续时间
PLoS Curr. 2015 May 20;7:ecurrents.dis.8a93e7682624698558a76a1fa8c5893f. doi: 10.1371/currents.dis.8a93e7682624698558a76a1fa8c5893f.