Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan.
J Mater Chem B. 2019 Apr 7;7(13):2123-2129. doi: 10.1039/c9tb00256a. Epub 2019 Mar 6.
The molecular mobility of cyclic molecules (e.g.α-cyclodextrins) threaded along a linear polymer chain (e.g. poly(ethylene glycol)) in polyrotaxanes is a unique feature for biomaterials with dynamic functionality. Surfaces with molecular mobility can be obtained by introducing polyrotaxanes. The molecular mobility of polyrotaxane-based surfaces can be modulated by changing the number of threaded cyclic molecules and modifying their functional groups. Biological ligands modified with α-cyclodextrins exhibit increased multivalent interactions with their receptors due to the molecular mobility of the latter. Furthermore, polyrotaxane-based surfaces not only improve the initial response of cells via multivalent interactions, but also affect cytoskeleton formation and the inherent quality of cells, including differentiation. Such polyrotaxane surfaces can emerge as new biointerfaces that can adapt to the dynamic biological nature.
聚轮烷中环分子（如α-环糊精）沿线性聚合物链（如聚乙二醇）的分子迁移性是具有动态功能的生物材料的独特特征。通过引入聚轮烷可以获得具有分子迁移性的表面。通过改变穿入的环分子数量和修饰其官能团，可以调节基于聚轮烷的表面的分子迁移性。用α-环糊精修饰的生物配体由于后者的分子迁移性而与受体表现出增加的多价相互作用。此外，基于聚轮烷的表面不仅通过多价相互作用改善细胞的初始反应，而且还影响细胞骨架的形成和细胞的固有性质，包括分化。这样的聚轮烷表面可以成为新的生物界面，能够适应动态的生物本性。
