美金刚治疗偏头痛的疗效：随机对照研究的荟萃分析。

The Efficacy of Memantine for the Treatment of Migraine: A Meta-Analysis of Randomized Controlled Studies.

机构信息

Department of Nephrology-Wenzhou People's Hospital, Zhejiang Province, China.

出版信息

Clin Neuropharmacol. 2021;44(3):94-98. doi: 10.1097/WNF.0000000000000425.

DOI:10.1097/WNF.0000000000000425

PMID:33961371

Abstract

INTRODUCTION

The efficacy of memantine for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of memantine versus placebo on treatment in migraine patients.

METHODS

We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through February 2020 for randomized controlled trials assessing the effect of memantine versus placebo on treatment efficacy in migraine patients. This meta-analysis is performed using the random-effect model.

RESULTS

Three randomized controlled trials are included in the meta-analysis. Overall, compared with control group in migraine patients, memantine treatment is associated with substantially reduced monthly attack frequency (mean difference [MD], -2.14; 95% confidence interval [CI], -2.83 to -1.46; P < 0.00001), number of migraine days (MD, -4.17; 95% CI, -6.40 to -1.93; P = 0.0003) and Migraine Disability Assessment (MD, -5.63; 95% CI, -6.46 to -4.79; P < 0.00001), but demonstrates no obvious influence on acute pain medications (MD, -1.23; 95% CI, -4.63 to 2.17; P = 0.48).

CONCLUSIONS

Memantine treatment may benefit to the control of migraine.

摘要

简介

美金刚治疗偏头痛的疗效仍存在争议。我们进行了一项系统评价和荟萃分析，以探讨美金刚与安慰剂相比对偏头痛患者治疗的影响。

方法

我们通过检索 PubMed、EMbase、Web of science、EBSCO 和 Cochrane 图书馆数据库，截至 2020 年 2 月，评估了美金刚与安慰剂相比对偏头痛患者治疗效果的随机对照试验。该荟萃分析采用随机效应模型进行。

结果

共有 3 项随机对照试验纳入荟萃分析。总体而言，与偏头痛患者的对照组相比，美金刚治疗与每月发作频率显著降低相关（平均差异 [MD]，-2.14；95%置信区间 [CI]，-2.83 至-1.46；P<0.00001）、偏头痛天数（MD，-4.17；95%CI，-6.40 至-1.93；P=0.0003）和偏头痛残疾评估（MD，-5.63；95%CI，-6.46 至-4.79；P<0.00001），但对急性疼痛药物无明显影响（MD，-1.23；95%CI，-4.63 至 2.17；P=0.48）。