Zhang Weiwei, Hu Huan, Cheng Haixia, Liu Qinghuai, Yuan Dongqing
Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
Department of Ophthalmology, Xishui People's Hospital Affiliated to Hubei University of Science and Technology, Huanggang, Hubei Province, People's Republic of China.
Clin Ophthalmol. 2020 Dec 2;14:4221-4228. doi: 10.2147/OPTH.S286372. eCollection 2020.
To evaluate the changes in vessel density in patients with unilateral congenital cataract after cataract extraction.
Children with unilateral congenital cataract were enrolled in our study. All of the patients underwent congenital cataract extraction and intraocular lens (IOL) implantation successfully. Optical coherence tomography angiography (OCTA) was performed to image the retinal vasculature in the macular and optic disc areas before and after surgery. The differences in vessel density and retinal thickness between groups were compared.
We found that the best corrected visual acuity (BCVA) was significantly improved one month after surgery compared with that before surgery (t=5.179, p<0.001). The axial length was also changed one month after surgery (t=5.350, p<0.001). The vessel density in the macular and optic disc areas of the affected eyes was significantly lower than that in the normal eyes, while the vessel density at the posterior pole was significantly improved one month after cataract extraction.
The decrease in vessel density in the macular and optic disc areas might be a consequence of the congenital cataract. Cataract extraction can relieve the form deprivation of the affected eye and increase the vessel density at the posterior pole of the affected eye significantly.
评估单侧先天性白内障患者白内障摘除术后血管密度的变化。
纳入单侧先天性白内障患儿进行本研究。所有患者均成功接受先天性白内障摘除及人工晶状体（IOL）植入术。术前及术后行光学相干断层扫描血管造影（OCTA）以成像黄斑和视盘区域的视网膜血管系统。比较各组间血管密度和视网膜厚度的差异。
我们发现术后1个月最佳矫正视力（BCVA）较术前显著提高（t = 5.179，p < 0.001）。术后1个月眼轴长度也发生了变化（t = 5.350，p < 0.001）。患眼黄斑和视盘区域的血管密度显著低于正常眼，而白内障摘除术后1个月后极部血管密度显著改善。
黄斑和视盘区域血管密度降低可能是先天性白内障的结果。白内障摘除可减轻患眼的形觉剥夺，并显著增加患眼后极部的血管密度。
