Xia Xi, Cole Susan P C, Cai Tiange, Cai Yu
School of Pharmacy, Institute of Oncology, Jinan University, Guangzhou, Guangdong 510632, P.R. China.
Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute, Kingston, ON K7L 3N6, Canada.
Oncol Lett. 2017 Jun;13(6):3989-3996. doi: 10.3892/ol.2017.5976. Epub 2017 Apr 3.
Multidrug resistance (MDR) is a major cause of chemotherapy failure. It occurs when an organism is resistant to one type of drug, but also develops resistance to other drugs with different structures and targets. There is a high incidence of MDR in cancer chemotherapy, therefore, finding an effective and non-toxic MDR reversal agent is an important goal, particularly for P-glycoprotein-mediated MDR in cancer. Improvements continue to be made to the status and understanding of traditional Chinese medicine (TCM), due to the advantages of low toxicity and relatively minor side effects. Therefore TCM is currently being used in the treatment of various types of diseases. In recent years, numerous components of TCM have been identified to be effective in reversing MDR by downregulating expression of the drug transporter membrane protein, recovering changes in enzymes involved in detoxification and metabolism and repairing the cell apoptosis pathway. The present study summarizes the anticancerous properties and MDR reversing components of traditional medicinal plants commonly used in the treatment of cancer.
多药耐药（MDR）是化疗失败的主要原因。当生物体对一种药物产生耐药性，同时也对其他具有不同结构和靶点的药物产生耐药性时，就会发生多药耐药。在癌症化疗中，多药耐药的发生率很高，因此，找到一种有效且无毒的多药耐药逆转剂是一个重要目标，特别是对于癌症中P-糖蛋白介导的多药耐药。由于传统中药（TCM）具有低毒性和相对较小副作用的优点，其地位和认知不断得到改善。因此，目前传统中药正在用于治疗各种类型的疾病。近年来，已确定许多传统中药成分可通过下调药物转运体膜蛋白的表达、恢复参与解毒和代谢的酶的变化以及修复细胞凋亡途径来有效逆转多药耐药。本研究总结了常用于治疗癌症的传统药用植物的抗癌特性和多药耐药逆转成分。
