NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China.
J Exp Clin Cancer Res. 2021 Apr 29;40(1):146. doi: 10.1186/s13046-021-01952-4.
The N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic modification, which is co-transcriptionally deposited by a methyltransferase complex, removed by a demethylase, and recognized by reader proteins. Mechanistically, m6A modification regulates the expression levels of mRNA and nocoding RNA by modulating the fate of modified RNA molecules, such as RNA splicing, nuclear transport, translation, and stability. Several studies have shown that m6A modification is dysregulated in the progression of multiple diseases, especially human tumors. We emphasized that the dysregulation of m6A modification affects different signal transduction pathways and involves in the biological processes underlying tumor cell proliferation, apoptosis, invasion and migration, and metabolic reprogramming, and discuss the effects on different cancer treatment.
N6-甲基腺苷（m6A）修饰是一种动态且可逆的表观遗传修饰，由甲基转移酶复合物共转录沉积，由去甲基化酶去除，并被阅读器蛋白识别。从机制上讲，m6A 修饰通过调节修饰 RNA 分子的命运，如 RNA 剪接、核转运、翻译和稳定性，来调节 mRNA 和非编码 RNA 的表达水平。有几项研究表明，m6A 修饰在多种疾病的进展中失调，特别是在人类肿瘤中。我们强调，m6A 修饰的失调会影响不同的信号转导通路，并涉及肿瘤细胞增殖、凋亡、侵袭和迁移以及代谢重编程等生物学过程，并讨论了对不同癌症治疗的影响。
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