CSIR-Central Scientific Instruments Organisation, Sector 30-C, Chandigarh-160030, India.
Faraday Discuss. 2021 Apr 1;227:204-212. doi: 10.1039/c9fd00111e. Epub 2020 Dec 9.
The use of hexagonal boron nitride quantum dots (hBN QDs) as an electrochemical sensor for ferritin is reported for the first time. These QDs were synthesized using a simple liquid exfoliation method. The synthesized material was characterized using analytical techniques such as UV-visible, Fourier transform infrared (FTIR) and Raman spectroscopy, X-ray diffraction (XRD), and high-resolution transmission electron microscopy (HR-TEM) to study different aspects of the QDs. These QDs were explored for their plausible application as a platform for the electrochemical detection of ferritin. For this, electrochemical impedance spectroscopy was used as a sensing technique and disposable hBN QD functionalized screen printed electrodes were used as a sensing platform. The developed immunosensor had a dynamic linear range from 10-2000 ng mL of ferritin concentration with a limit of detection of 1.306 ng mL. The immunosensor was highly selective, did not deviate in the presence of interfering agents and was also highly reproducible.
首次报道了六方氮化硼量子点（hBN QDs）在铁蛋白电化学传感器中的应用。这些 QDs 是通过简单的液相剥离法合成的。使用分析技术如紫外-可见分光光度法、傅里叶变换红外（FTIR）和拉曼光谱、X 射线衍射（XRD）和高分辨率透射电子显微镜（HR-TEM）对合成材料进行了表征，以研究 QDs 的不同方面。这些 QDs 被探索用于作为电化学检测铁蛋白的平台。为此，电化学阻抗谱被用作传感技术，并且使用一次性 hBN QD 功能化的丝网印刷电极作为传感平台。所开发的免疫传感器具有 10-2000ng mL 铁蛋白浓度的动态线性范围，检测限为 1.306ng mL。该免疫传感器具有高选择性，在存在干扰物时不会偏离，并且还具有高度重现性。
