Yang Fengmin, Li Qian, Xiang Junfeng, Zhang Hong, Sun Hongxia, Ruan Guorui, Tang Yalin
National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. China.
Mol Omics. 2021 Feb 1;17(1):153-159. doi: 10.1039/d0mo00067a. Epub 2020 Dec 9.
Acute lymphoblastic leukemia (ALL) is one of the common malignant tumors. Compared with childhood ALL, the treatment effect of adult B-cell ALL is less effective and remains a big challenge. In order to explore the pathogenesis of adult B-cell ALL and find new diagnostic biomarkers to develop sensitive diagnostic tools, we investigated the plasma metabolites of adult B-cell ALL by using H NMR (nuclear magnetic resonance) metabolomics. Relative to healthy controls, adult B-cell ALL patients showed abnormal metabolism, including glycolysis, gluconeogenesis, amino acid metabolism, fatty acid metabolism and choline phospholipid metabolism. What's more important, we also found that the optimal combination of choline, tyrosine and unsaturated lipids has the potential to diagnose and prognose adult B-cell ALL in the clinic.
急性淋巴细胞白血病（ALL）是常见的恶性肿瘤之一。与儿童ALL相比，成人B细胞ALL的治疗效果较差，仍然是一个巨大的挑战。为了探索成人B细胞ALL的发病机制，并寻找新的诊断生物标志物以开发灵敏的诊断工具，我们采用氢核磁共振（H NMR）代谢组学技术研究了成人B细胞ALL患者的血浆代谢物。相对于健康对照，成人B细胞ALL患者表现出代谢异常，包括糖酵解、糖异生、氨基酸代谢、脂肪酸代谢和胆碱磷脂代谢。更重要的是，我们还发现胆碱、酪氨酸和不饱和脂质的最佳组合在临床上具有诊断和预测成人B细胞ALL的潜力。
