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新兴病毒株修正多株 SIR 模型的局部稳定性。

The local stability of a modified multi-strain SIR model for emerging viral strains.

机构信息

Department of Statistics, University of Nebraska-Lincoln, Lincoln, NE, United States of America.

出版信息

PLoS One. 2020 Dec 9;15(12):e0243408. doi: 10.1371/journal.pone.0243408. eCollection 2020.

Abstract

We study a novel multi-strain SIR epidemic model with selective immunity by vaccination. A newer strain is made to emerge in the population when a preexisting strain has reached equilbrium. We assume that this newer strain does not exhibit cross-immunity with the original strain, hence those who are vaccinated and recovered from the original strain become susceptible to the newer strain. Recent events involving the COVID-19 virus shows that it is possible for a viral strain to emerge from a population at a time when the influenza virus, a well-known virus with a vaccine readily available, is active in a population. We solved for four different equilibrium points and investigated the conditions for existence and local stability. The reproduction number was also determined for the epidemiological model and found to be consistent with the local stability condition for the disease-free equilibrium.

摘要

我们研究了一种新型的多菌株 SIR 传染病模型,该模型通过接种疫苗具有选择性免疫。当一种现有菌株达到平衡时,一种新菌株会在人群中出现。我们假设这种新菌株与原始菌株没有交叉免疫性,因此那些接种疫苗并从原始菌株中康复的人会对新菌株易感。最近涉及 COVID-19 病毒的事件表明,当流感病毒(一种具有现成疫苗的知名病毒)在人群中活跃时,一种病毒株有可能从人群中出现。我们求解了四个不同的平衡点,并研究了存在和局部稳定性的条件。还确定了传染病模型的繁殖数,并发现其与无病平衡点的局部稳定性条件一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5103/7725381/948411d268b6/pone.0243408.g001.jpg

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