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未来健康小学计划的终身成本效益和公平性影响。

Lifetime cost-effectiveness and equity impacts of the Healthy Primary School of the Future initiative.

机构信息

Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Center MUMC+/ Care and Public Health Research Institute (CAPHRI), Maastricht University, P.O. Box 5800, 6202, AZ, Maastricht, The Netherlands.

Centre for Nutrition, Prevention and Health Services, National Institute of Public Health and the Environment, Bilthoven, the Netherlands.

出版信息

BMC Public Health. 2020 Dec 9;20(1):1887. doi: 10.1186/s12889-020-09744-9.

Abstract

BACKGROUND

This study estimated the lifetime cost-effectiveness and equity impacts associated with two lifestyle interventions in the Dutch primary school setting (targeting 4-12 year olds).

METHODS

The Healthy Primary School of the Future (HPSF; a healthy school lunch and structured physical activity) and the Physical Activity School (PAS; structured physical activity) were compared to the regular Dutch curriculum (N = 1676). An adolescence model, calculating weight development, and the RIVM Chronic Disease Model, calculating overweight-related chronic diseases, were linked to estimate the lifetime impact on chronic diseases, quality adjusted life years (QALYs), healthcare, and productivity costs. Cost-effectiveness was expressed as the additional costs/QALY gained and we used €20,000 as threshold. Scenario analyses accounted for alternative effect maintenance scenarios and equity analyses examined cost-effectiveness in different socioeconomic status (SES) groups.

RESULTS

HPSF resulted in a lifetime costs of €773 (societal perspective) and a lifetime QALY gain of 0.039 per child versus control schools. HPSF led to lower costs and more QALYs as compared to PAS. From a societal perspective, HPSF had a cost/QALY gained of €19,734 versus control schools, 50% probability of being cost-effective, and beneficial equity impact (0.02 QALYs gained/child for low versus high SES). The cost-effectiveness threshold was surpassed when intervention effects decayed over time.

CONCLUSIONS

HPSF may be a cost-effective and equitable strategy for combatting the lifetime burden of unhealthy lifestyles. The win-win situation will, however, only be realised if the intervention effect is sustained into adulthood for all SES groups.

TRIAL REGISTRATION

Clinicaltrials.gov ( NCT02800616 ). Registered 15 June 2016 - Retrospectively registered.

摘要

背景

本研究旨在评估在荷兰小学环境中开展两种生活方式干预措施(针对 4-12 岁儿童)的终生成本效益和公平影响。

方法

将“未来健康小学”(HPSF;健康学校午餐和结构化体育活动)和“体育活动学校”(PAS;结构化体育活动)与荷兰常规课程(N=1676 名学生)进行比较。通过青少年模型计算体重发育情况,以及 RIVM 慢性病模型计算超重相关的慢性病,来估计对慢性病、健康调整生命年(QALYs)、医疗保健和生产力成本的终生影响。成本效益以每增加一个质量调整生命年的额外成本来表示,我们使用 20000 欧元作为阈值。情景分析考虑了替代效果维持情景,公平性分析则考察了不同社会经济地位(SES)群体的成本效益。

结果

从社会角度来看,HPSF 的终生成本为 773 欧元(HPSF 与对照学校相比,终生 QALY 增加了 0.039 个单位。HPSF 的成本低于 PAS,QALY 也更多。从社会角度来看,HPSF 的成本/QALY 增加为 19734 欧元,对照学校为 50%的概率具有成本效益,对低收入和高收入 SES 群体均有公平效益(低收入 SES 群体的 QALY 增加 0.02 个单位)。当干预效果随时间衰减时,成本效益阈值就会被超过。

结论

HPSF 可能是对抗不健康生活方式终生负担的一种具有成本效益和公平性的策略。然而,只有在所有 SES 群体中,干预效果持续到成年期,这种双赢局面才会实现。

试验注册

Clinicaltrials.gov(NCT02800616)。2016 年 6 月 15 日注册-回顾性注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/598c/7724829/a75e68c9c1e8/12889_2020_9744_Fig1_HTML.jpg

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