Ramsperger A F R M, Narayana V K B, Gross W, Mohanraj J, Thelakkat M, Greiner A, Schmalz H, Kress H, Laforsch C
Animal Ecology I and BayCEER, University of Bayreuth, Bayreuth, Germany.
Biological Physics, University of Bayreuth, Bayreuth, Germany.
Sci Adv. 2020 Dec 9;6(50). doi: 10.1126/sciadv.abd1211. Print 2020 Dec.
Microplastic particles ubiquitously found in the environment are ingested by a huge variety of organisms. Subsequently, microplastic particles can translocate from the gastrointestinal tract into the tissues likely by cellular internalization. The reason for cellular internalization is unknown, since this has only been shown for specifically surface-functionalized particles. We show that environmentally exposed microplastic particles were internalized significantly more often than pristine microplastic particles into macrophages. We identified biomolecules forming an eco-corona on the surface of microplastic particles, suggesting that environmental exposure promotes the cellular internalization of microplastics. Our findings further indicate that cellular internalization is a key route by which microplastic particles translocate into tissues, where they may cause toxicological effects that have implications for the environment and human health.
环境中普遍存在的微塑料颗粒被各种各样的生物体摄入。随后，微塑料颗粒可能通过细胞内化作用从胃肠道转移到组织中。细胞内化的原因尚不清楚，因为这仅在特定表面功能化颗粒中得到证实。我们发现，与原始微塑料颗粒相比，暴露于环境中的微塑料颗粒被巨噬细胞内化的频率要高得多。我们鉴定出在微塑料颗粒表面形成生态冠的生物分子，这表明环境暴露促进了微塑料的细胞内化。我们的研究结果进一步表明，细胞内化是微塑料颗粒转移到组织中的关键途径，在组织中它们可能会产生对环境和人类健康有影响的毒理学效应。
