Center of Oral Implantology, Stomatological Hospital, Southern Medical University, Guangzhou 510280, People's Republic of China.
Department of Oral and Maxillofacial Surgery, Inner Mongolia People' Hospital, Huhhot, Inner Mongolia 010017, People's Republic of China.
Int J Nanomedicine. 2020 Dec 2;15:9639-9655. doi: 10.2147/IJN.S275373. eCollection 2020.
Improvements in the early osseointegration of titanium implants require investigations on the bone-implant interface, which is a critical and complex challenge. The surface cleanliness of titanium implants plays an important role at this interface. However, the implant surface would inevitably absorb contamination such as organic hydrocarbons, which is not conductive to the establishment of early osseointegration. Herein, an optimized approach for removing contamination from titanium surfaces was studied.
The TiO-B＠anatase NWs (nanowires) were prepared on titanium substrates through a hydrothermal process. A methylene blue degradation experiment was performed to assess the photodegradation activity. The cleaning effect of the photocatalysis of TiO-B＠anatase NWs on a titanium surface and the cellular early response was determined by analyzing cell morphology, attachment, proliferation and differentiation.
The results indicated that the photocatalysis of TiO-B＠anatase NWs could effectively remove hydrocarbons on titanium surfaces without sacrificing the favourable titanium surface morphology. The methylene blue degradation experiment revealed that the photocatalysis of TiO-B＠anatase NWs had powerful degradation activity, which is attributed to the presence of strong oxidants such as OH. In addition, compared to the merely ultraviolet-treated titanium surfaces, the titanium surfaces treated after the NWs photocatalytic cleaning process markedly enhanced cellular early response.
The photocatalysis of TiO-B＠anatase NWs for the removal of contamination from titanium surfaces has the potential to enable the rapid and complete establishment of early osseointegration.
提高钛植入物的早期骨整合需要对骨-植入物界面进行研究，这是一个关键且复杂的挑战。钛植入物的表面清洁度在这个界面中起着重要作用。然而，植入物表面不可避免地会吸收有机碳氢化合物等污染物，这不利于早期骨整合的建立。在此，研究了一种优化的钛表面污染物去除方法。
通过水热法在钛基体上制备 TiO-B＠锐钛矿 NWs（纳米线）。通过亚甲基蓝降解实验评估光催化活性。通过分析细胞形态、黏附、增殖和分化来确定 TiO-B＠锐钛矿 NWs 对钛表面的光催化清洁效果和细胞早期反应。
结果表明，TiO-B＠锐钛矿 NWs 的光催化作用可以有效地去除钛表面的碳氢化合物，而不会牺牲有利的钛表面形貌。亚甲基蓝降解实验表明，TiO-B＠锐钛矿 NWs 的光催化作用具有强大的降解活性，这归因于存在强氧化剂如 OH。此外，与仅经紫外线处理的钛表面相比，经 NWs 光催化清洁处理后的钛表面显著增强了细胞早期反应。
TiO-B＠锐钛矿 NWs 对钛表面污染物的光催化去除具有促进早期骨整合快速完全建立的潜力。
