Newman William Christopher, Patel Ankur, Goldberg Jacob L, Bilsky Mark H
Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Department of Neurosurgery, Baylor University Medical Center, Dallas, Texas.
Neurooncol Pract. 2020 Nov 18;7(Suppl 1):i25-i32. doi: 10.1093/nop/npaa056. eCollection 2020 Nov.
Spine metastases are very common in cancer patients often requiring urgent assessment and the initiation of therapy. Treatment paradigms have changed exponentially over the past decade with the evolution and integration of stereotactic body radiotherapy, minimally invasive spine techniques, and systemic options including biologics and checkpoint inhibitors. These advances necessitate multidisciplinary assessments and interventions to optimize outcomes. The NOMS framework provides a mechanism for all practitioners to evaluate the 4 sentinel assessments required to make decisions in patients with spine metastases: Neurologic, Oncologic, Mechanical Stability, and Systemic disease. The NOMS framework is continuously updated with the integration of newer technologies and evidence-based medicine as they become available. This paper presents the current iteration of NOMS with a focus on the role of medical and neuro-oncologists in the assessment and treatment of metastatic spine tumors.
脊柱转移瘤在癌症患者中非常常见,通常需要进行紧急评估并开始治疗。在过去十年中,随着立体定向体部放疗、微创脊柱技术以及包括生物制剂和检查点抑制剂在内的全身治疗方案的发展和整合,治疗模式发生了巨大变化。这些进展需要多学科评估和干预以优化治疗效果。NOMS框架为所有从业者提供了一种机制,用于评估脊柱转移瘤患者决策所需的4项关键评估:神经学、肿瘤学、机械稳定性和全身疾病。随着新技术和循证医学的不断涌现,NOMS框架也在持续更新。本文介绍了NOMS的当前版本,重点阐述了医学肿瘤学家和神经肿瘤学家在转移性脊柱肿瘤评估和治疗中的作用。