Infertility Research Center, Research center of Quran, Hadith and medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Vali Asr Educational Hospital Arsanjan, University of Medical science's Shiraz, Iran.
Mini Rev Med Chem. 2021;21(10):1226-1236. doi: 10.2174/1389557520999201209213319.
Male infertility is one of the major global health problems, in particular, in more than half of the affected men. Genetic factors are important for identifying men with idiopathic infertility along with semen analysis. Valid and useful information can be obtained through non-invasive molecular research. Among these, small single-stranded non-coding RNA molecules of microRNAs (abbreviated miRNAs) are non-invasive biomarkers with a diagnostic value by regulating the post-transcriptional gene silence through repression and prevention of the translation process. The association between various types of male infertility and miRNA regulation changes has been evaluated to understand the biological function of miRNA and gene targets. Accordingly, further study of the function of miRNAs associated with reproductive disorders could lead researchers to further understand the molecular mechanisms of male infertility in order to find effective biomarkers and therapeutic strategies. Therefore, the present review article aimed at scrutinizing those researches investigating the altered miRNA expression in testicles, epididymis, and spermatozoa.
男性不育是全球主要的健康问题之一，尤其是在一半以上的受影响男性中。遗传因素对于识别特发性不育症患者以及精液分析很重要。通过非侵入性的分子研究可以获得有效和有用的信息。其中，微小 RNA（miRNA）等小型单链非编码 RNA 分子是具有诊断价值的非侵入性生物标志物，通过抑制和阻止翻译过程来调节转录后基因沉默。已经评估了各种类型的男性不育症与 miRNA 调控变化之间的关联，以了解 miRNA 和基因靶标的生物学功能。因此，进一步研究与生殖障碍相关的 miRNA 的功能可以使研究人员进一步了解男性不育的分子机制，以找到有效的生物标志物和治疗策略。因此，本文旨在仔细研究那些研究睾丸、附睾和精子中 miRNA 表达改变的研究。
