Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Dipartimento di Scienze Mediche e Chirurgiche, 00168 Roma, Italia.
Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Unità Operativa Semplice di Psicologia Clinica Ospedaliera, 00168 Roma, Italia.
Dig Liver Dis. 2021 Mar;53(3):298-305. doi: 10.1016/j.dld.2020.11.026. Epub 2020 Dec 7.
Research increasingly demonstrates the bidirectional communication between gut microbiota and the brain, enhancing the role of gut microbiota modulation in the treatment of central nervous system (CNS) disorders. The first five years of life are extremely important as it affects the development of gut microbiota, immune system and, consequently, the onset of psychometric alterations, particularly in genetically predisposed individuals. In this review, we focus on the link between specific microbial genera, gastrointestinal (GI) disorders, anxiety and depression and on the effects of different therapeutic strategies for mood disorders on gut microbiota.
研究越来越多地表明肠道微生物群和大脑之间的双向通讯，增强了肠道微生物群调节在治疗中枢神经系统（CNS）障碍中的作用。生命的头五年非常重要，因为它会影响肠道微生物群、免疫系统的发育，从而导致心理测量学改变的发生，特别是在遗传易感性个体中。在这篇综述中，我们重点关注特定微生物属与胃肠道（GI）疾病、焦虑和抑郁之间的联系，以及不同的治疗策略对肠道微生物群和情绪障碍的影响。
