粘性恶性间皮瘤胸腔积液中的透明质酸

Cheah Hui Min, Fitzgerald Deirdre, Louw Amber, Creaney Jenette, Lee Y C Gary

Pleural Medicine Unit Center for Respiratory Health, University of Western Australia Perth WA Australia.

Medical School University of Western Australia Perth WA Australia.

Respirol Case Rep. 2020 Dec 3;9(1):e00694. doi: 10.1002/rcr2.694. eCollection 2021 Jan.

Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity-dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight.

恶性胸腔积液（MPE）在间皮瘤中很常见。我们报告了两例与间皮瘤相关的异常黏稠的MPE病例。这种黏稠度使得通过留置胸腔导管进行自然重力引流变得不可能。我们的体外实验发现，积液中的透明质酸（HA）含量非常高。用透明质酸酶而非脱氧核糖核酸酶处理积液，可显著降低积液的黏稠度。这些结果证明，HA可能导致间皮瘤患者胸腔积液的高黏稠度。研究在MPE治疗中对抗HA特性的策略可能会提供更多见解。