哺乳动物胚胎中对称性破缺的自组织框架。
A self-organization framework for symmetry breaking in the mammalian embryo.
机构信息
Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
出版信息
Nat Rev Mol Cell Biol. 2013 Jul;14(7):452-9. doi: 10.1038/nrm3602. Epub 2013 Jun 19.
DOI:10.1038/nrm3602
PMID:23778971
Abstract
The mechanisms underlying the appearance of asymmetry between cells in the early embryo and consequently the specification of distinct cell lineages during mammalian development remain elusive. Recent experimental advances have revealed unexpected dynamics of and new complexity in this process. These findings can be integrated in a new unified framework that regards the early mammalian embryo as a self-organizing system.
摘要
早期胚胎中细胞出现不对称性的机制，以及哺乳动物发育过程中不同细胞谱系的特化，其背后的原理仍然难以捉摸。最近的实验进展揭示了这个过程中出人意料的动态和新的复杂性。这些发现可以整合到一个新的统一框架中，该框架将早期哺乳动物胚胎视为一个自组织系统。
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