Musillo Chiara, Borgi Marta, Saul Nadine, Möller Steffen, Luyten Walter, Berry Alessandra, Cirulli Francesca
Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy; PhD Program in Behavioral Neuroscience, Department of Psychology, Sapienza University of Rome, Rome, Italy.
Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Neurosci Biobehav Rev. 2021 Feb;121:89-105. doi: 10.1016/j.neubiorev.2020.12.001. Epub 2020 Dec 9.
Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; "healthspan" is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth.
在过去几十年里，死亡率的下降为心血管疾病、代谢性疾病或神经退行性疾病等迟发性疾病铺平了道路。这一证据促使许多研究人员将重点从研究延长寿命的方法转向寻找增加健康寿命年数的方法；“健康寿命”确实是这种追求无慢性或致残性疾病及功能障碍的衰老方式的新兴概念。经常食用天然产物可能会改善健康寿命，尽管其作用机制仍知之甚少。由于旨在评估这些化合物功效和安全性的临床前研究不断增加，我们对天然产物对生理衰老小鼠和大鼠模型健康寿命的影响进行了系统综述和荟萃分析。结果表明，天然化合物在提高抗应激能力和认知能力方面显示出强大作用。这些有前景的数据呼吁进一步深入研究其潜在机制。
