Center for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Institute of Experimental Endocrinology and Diabetology, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.
Nutrients. 2023 Jul 28;15(15):3366. doi: 10.3390/nu15153366.
A growing body of evidence suggests that regular consumption of natural products might promote healthy aging; however, their mechanisms of action are still unclear. Rosmarinic acid (RA) is a polyphenol holding anti-inflammatory, antioxidant and neuroprotective properties. The aim of this study was to characterise the efficacy of an oral administration of RA in promoting healthspan in a mouse model of physiological aging. Aged C57Bl/6 male and female (24-month-old) mice were either administered with RA (500 mg/Kg) or a vehicle in drinking bottles for 52 days while 3-month-old mice receiving the same treatment were used as controls. All subjects were assessed for cognitive abilities in the Morris water maze (MWM) and for emotionality in the elevated-plus maze test (EPM). Brain-derived Neurotrophic Factor (BDNF) protein levels were evaluated in the hippocampus. Since the interaction between metabolic signals and cerebral functions plays a pivotal role in the etiopathogenesis of cognitive decline, the glycaemic and lipid profiles of the mice were also assessed. RA enhanced learning and memory in 24-month-old mice, an effect that was associated to improved glucose homeostasis. By contrast, the lipid profile was disrupted in young adults. This effect was associated with worse glycaemic control in males and with reduced BDNF levels in females, suggesting powerful sex-dependent effects and raising a note of caution for RA administration in young healthy adult subjects.
越来越多的证据表明，经常食用天然产品可能有助于健康衰老；然而，其作用机制尚不清楚。迷迭香酸（RA）是一种具有抗炎、抗氧化和神经保护作用的多酚。本研究旨在描述 RA 口服给药在促进生理衰老小鼠健康寿命方面的功效。雄性和雌性 C57Bl/6 老年（24 月龄）小鼠分别通过饮水瓶给予 RA（500mg/kg）或载体，3 月龄接受相同处理的小鼠作为对照。所有研究对象均在 Morris 水迷宫（MWM）中评估认知能力，在高架十字迷宫测试（EPM）中评估情绪。评估海马体中的脑源性神经营养因子（BDNF）蛋白水平。由于代谢信号和大脑功能之间的相互作用在认知能力下降的发病机制中起着关键作用，还评估了小鼠的血糖和血脂谱。RA 增强了 24 月龄小鼠的学习和记忆能力，这种作用与改善葡萄糖稳态有关。相比之下，年轻成年人的脂质谱被打乱。这种作用与男性血糖控制较差以及女性 BDNF 水平降低有关，这表明 RA 对年轻健康成年个体具有强大的性别依赖性影响，并提醒人们谨慎使用 RA。
