INSERM U1093, Univ. Bourgogne Franche-Comté, Dijon, F-21000, France.
EA4267 PEPITE, FHU INCREASE, Univ. Bourgogne Franche-Comté, Besançon, F-25030, France.
Rheumatology (Oxford). 2021 Apr 6;60(4):1608-1619. doi: 10.1093/rheumatology/keaa849.
Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease characterized by synovitis leading to joint destruction, pain and disability. Despite efficient antirheumatic drugs, neuropsychiatric troubles including depression and cognitive dysfunction are common in RA but the underlying mechanisms are unclear. However, converging evidence strongly suggests that deficit in brain-derived neurotrophic factor (BDNF) signalling contributes to impaired cognition and depression. Therefore, this review summarizes the current knowledge on BDNF in RA, proposes possible mechanisms linking RA and brain BDNF deficiency including neuroinflammation, cerebral endothelial dysfunction and sedentary behaviour, and discusses neuromuscular electrical stimulation as an attractive therapeutic option.
类风湿关节炎（RA）是一种自身免疫性慢性炎症性疾病，其特征为滑膜炎导致关节破坏、疼痛和残疾。尽管有高效的抗风湿药物，但包括抑郁和认知功能障碍在内的神经精神问题在 RA 中很常见，但潜在机制尚不清楚。然而，越来越多的证据强烈表明，脑源性神经营养因子（BDNF）信号的缺陷导致认知功能障碍和抑郁。因此，本综述总结了 BDNF 在 RA 中的现有知识，提出了可能将 RA 与大脑 BDNF 缺乏联系起来的机制，包括神经炎症、脑内皮功能障碍和久坐行为，并讨论了神经肌肉电刺激作为一种有吸引力的治疗选择。
