Zang Xinlong, Zhou Jingyi, Zhang Xiaoxu, Han Yantao, Chen Xuehong
School of Basic Medicine, Qingdao University, Ningxia Road 308, Qingdao 110016, P.R. China.
ACS Biomater Sci Eng. 2020 Dec 14;6(12):6528-6539. doi: 10.1021/acsbiomaterials.0c01197. Epub 2020 Nov 24.
Ischemia reperfusion (IR)-induced oxidative stress, accompanied by inflammatory responses, contributes to morbidity and mortality in numerous diseases such as acute coronary syndrome, stroke, organ transplantation, and limb injury. Ischemia results in profound hypoxia and tissue dysfunction, whereas subsequent reperfusion further aggravates ischemic tissue damage through inducing cell death and activating inflammatory responses. In this review, we highlight recent studies of therapeutic strategies against IR injury. Furthermore, nanotechnology offers significant improvements in this area. Hence, we also review recent advances in nanomedicines for IR therapy, suggesting them as potent and promising strategies to improve drug delivery to IR-injured tissues and achieve protective effects.
缺血再灌注（IR）诱导的氧化应激，伴随着炎症反应，在许多疾病如急性冠状动脉综合征、中风、器官移植和肢体损伤中导致发病和死亡。缺血导致严重的缺氧和组织功能障碍，而随后的再灌注通过诱导细胞死亡和激活炎症反应进一步加重缺血组织损伤。在本综述中，我们重点介绍了针对IR损伤的治疗策略的最新研究。此外，纳米技术在这一领域有显著进展。因此，我们还综述了用于IR治疗的纳米药物的最新进展，表明它们是改善向IR损伤组织的药物递送并实现保护作用的有效且有前景的策略。
