Yu Chengpeng, Rao Dean, Wang Tiantian, Song Jia, Zhang Lei, Huang Wenjie
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Front Cell Dev Biol. 2022 Sep 19;10:1004429. doi: 10.3389/fcell.2022.1004429. eCollection 2022.
As a member of the TRIM protein family, TRIM27 is a RING-mediated E3 ubiquitin ligase that can mark other proteins for degradation. Its ubiquitination targets include PTEN, IκBα and p53, which allows it to regulate many signaling pathways to exert its functions under both physiological and pathological conditions, such as cell proliferation, differentiation and apoptosis. During the past decades, TRIM27 was reported to be involved in many diseases, including cancer, lupus nephritis, ischemia-reperfusion injury and Parkinson's disease. Although the research interest in TRIM27 is increasing, there are few reviews about the diverse roles of this protein. Here, we systematically review the roles of TRIM27 in cancer and other human diseases. Firstly, we introduce the biological functions of TRIM27. Next, we focus on the roles of TRIM27 in cancer, including ovarian cancer, breast cancer and lung cancer. At the same time, we also describe the roles of TRIM27 in other human diseases, such as lupus nephritis, ischemia-reperfusion injury and Parkinson's disease. Finally, we discuss the future directions of TRIM27 research, especially its potential roles in tumor immunity.
作为TRIM蛋白家族的一员，TRIM27是一种由RING介导的E3泛素连接酶，能够标记其他蛋白质以便降解。其泛素化靶点包括PTEN、IκBα和p53，这使得它能够调节多种信号通路，在生理和病理条件下发挥功能，如细胞增殖、分化和凋亡。在过去几十年中，据报道TRIM27参与了许多疾病，包括癌症、狼疮性肾炎、缺血再灌注损伤和帕金森病。尽管对TRIM27的研究兴趣日益增加，但关于该蛋白多种作用的综述却很少。在此，我们系统地综述了TRIM27在癌症和其他人类疾病中的作用。首先，我们介绍TRIM27的生物学功能。接下来，我们重点关注TRIM27在癌症中的作用，包括卵巢癌、乳腺癌和肺癌。同时，我们也描述TRIM27在其他人类疾病中的作用，如狼疮性肾炎、缺血再灌注损伤和帕金森病。最后，我们讨论TRIM27研究的未来方向，特别是其在肿瘤免疫中的潜在作用。
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