Woodhall Mark, Mitchell James W, Gibbons Emily, Healy Sarah, Waters Patrick, Huda Saif
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom.
Front Neurol. 2020 Nov 25;11:598531. doi: 10.3389/fneur.2020.598531. eCollection 2020.
A 39-year-old lady with relapsing myelin oligodendrocyte glycoprotein antibody (MOG-IgG) associated disease developed coryzal symptoms, malaise, sweating, and postural dizziness. Six days later she presented with painful progressive right visual loss consistent with optic neuritis. COVID-19 was confirmed by nasopharyngeal swab and MOG-IgG serological reversion was noted. Visual function improved following steroids and plasma exchange. This case highlights a possible causal association between inflammation due to COVID-19 and a relapse of MOG-IgG associated disease. It also highlights the clinical relevance of reporting MOG-IgG titers in MOG-IgG associated disease.
一名39岁患有复发性髓鞘少突胶质细胞糖蛋白抗体（MOG-IgG）相关疾病的女性出现了感冒症状、不适、出汗和体位性头晕。六天后，她出现了与视神经炎相符的进行性右侧视力疼痛减退。通过鼻咽拭子确诊为COVID-19，并注意到MOG-IgG血清学逆转。使用类固醇和血浆置换后视觉功能有所改善。该病例突出了COVID-19引起的炎症与MOG-IgG相关疾病复发之间可能存在的因果关系。它还突出了在MOG-IgG相关疾病中报告MOG-IgG滴度的临床相关性。
