Keshavarzi Abdolkhalegh, Mohammadi Ali Akbar, Ayaz Mehdi, Javanmardi Fatemeh, Hoghoughi Mohammad Ali, Shirazi Yeganeh Babak, Emami Amir, Mackie Mandana, Akrami Rahimeh, Iranpak Sorayya
Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.
Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
World J Plast Surg. 2020 Sep;9(3):331-338. doi: 10.29252/wjps.9.3.331.
Despite the whole world's effort for controlling an ongoing global outbreak caused by new corona virus; it is still a major public health issue. Any hospitalized patient or outpatient in burn departments should be considered as a potential infectious source of COVID-19, which may cause an overwhelming of disease. However, there are no previous experiences about COVID-19 in burn patients all over the world, and here we reported two burn cases at Amir-al-Momenin Burn Hospital Affiliated to Shiraz University of Medical Sciences, Shiraz, Iran with skin manifestations, which were detected as a rarely COVID-19 symptom. A 13-year-old girl [total body surface area (TBSA): 18%] and a 37-year-old woman (TBSA: 30%) who had burn injuries by gas explosion and car accident, respectively were enrolled. After admission, some vesicular injuries were visible in burn area. To confirm, skin biopsy specimens were either sent for histopathology examination or for real time polymerase chain reaction (PCR) as follow: Herpes Simplex Virus (HSV), chicken pox, and potassium hydroxide (KOH) for fungal infections. All test results were negative. Although they had no symptoms of COVID-19, two swabs from nasopharyngeal and oropharyngeal samplings were taken, the result was negative either. Specimens were obtained from vesicular lesions for qRT-PCR assay of COVID-19. According to the molecular results for vesicular samples, all the results were positive for COVID-19. Unlike all other COVID-19 patients who have respiratory symptoms, SARS-COV-2 appeared by cutaneous vesicular and blisters in two burn cases.
尽管全球都在努力控制由新型冠状病毒引发的持续全球疫情，但它仍然是一个重大的公共卫生问题。烧伤科的任何住院患者或门诊患者都应被视为 COVID-19 的潜在传染源，这可能导致疾病的大规模爆发。然而，世界各地此前尚无烧伤患者感染 COVID-19 的经验，在此我们报告了伊朗设拉子医科大学附属阿米尔-穆民宁烧伤医院的两例烧伤病例，这两名患者有皮肤表现，而皮肤表现是 COVID-19 中罕见的症状。纳入了一名 13 岁女孩（全身表面积 [TBSA]：18%）和一名 37 岁女性（TBSA：30%），她们分别因煤气爆炸和车祸而烧伤。入院后，烧伤部位可见一些水疱性损伤。为进行确诊，皮肤活检标本被送去进行组织病理学检查或实时聚合酶链反应（PCR）检测，检测项目如下：单纯疱疹病毒（HSV）、水痘以及用于真菌感染检测的氢氧化钾（KOH）。所有检测结果均为阴性。尽管她们没有 COVID-19 的症状，但仍采集了两份鼻咽和口咽拭子样本，结果也均为阴性。从水疱性损伤处获取标本进行 COVID-19 的定量逆转录聚合酶链反应（qRT-PCR）检测。根据水疱样本的分子检测结果，所有结果均显示 COVID-19 呈阳性。与所有其他有呼吸道症状的 COVID-19 患者不同，在这两例烧伤病例中，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）通过皮肤水疱出现。
