新型倍半萜酯类化合物来源于（L.）DC.及其抗流感病毒活性。

New sesquiterpeniod esters form (L.) DC. and their anti-influenza virus activity.

机构信息

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China.

The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China.

出版信息

Nat Prod Res. 2022 Mar;36(5):1151-1160. doi: 10.1080/14786419.2020.1861615. Epub 2020 Dec 17.

DOI:10.1080/14786419.2020.1861615

PMID:33331176

Abstract

Phytochemical studies led to the isolation of five new sesquiterpeniod esters, named balsamiferine N-R, along with ten known compounds (6-15) from the leaves of (L.) DC. The skeletons of nine known sesquiterpeniods belong to guaiane and eudesmane. The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic analysis, and quantum-chemical electronic circular dichroism (ECD) calculation. Compounds and showed significant inhibitory effects on influenza A virus (H3N2) with IC values of 46.23 μg/mL and 38.49 μg/mL, respectively. It was the first report on the anti-influenza A virus constituents from .

摘要

植物化学研究导致从（L.）DC 的叶子中分离出五个新的倍半萜内酯酯，命名为 balsamiferine N-R，以及十个已知化合物（6-15）。九个已知倍半萜内酯的骨架属于愈创木烷和艾里莫烷。通过综合光谱分析和量子化学电子圆二色性（ECD）计算，阐明了新化合物的结构及其绝对构型。化合物和对甲型流感病毒（H3N2）表现出显著的抑制作用，IC 值分别为 46.23μg/mL 和 38.49μg/mL。这是首次报道从中具有抗甲型流感病毒活性的成分。