Patient-centered Research, Evidera, Bethesda, MD, USA.
Formerly Patient and Health Impact, Pfizer Inc, New York, NY, USA.
Curr Med Res Opin. 2021 Mar;37(3):505-514. doi: 10.1080/03007995.2020.1865891. Epub 2021 Jan 18.
Content validation is essential in the development of patient-reported instruments to ensure relevancy and understandability. The aim was to evaluate patient understanding of the Prescription Opioid Misuse and Abuse Questionnaire (POMAQ) using cognitive interviewing among adults with chronic moderate to severe pain.
This qualitative study involved a one-time in-clinic visit to conduct one-on-one cognitive interviews among participants with chronic moderate to severe pain from four groups: (1) Known Opioid Abuse; (2) Known Abuse of Other Substances (e.g. alcohol, benzodiazepines); (3) Opioid Non-abuse; and (4) No Chronic Opioid Use. Patients were recruited from 6 US clinical centers. Concept elicitation questions regarding misuse and abuse were asked at interview start; the POMAQ was completed a web interface followed by a cognitive interview regarding POMAQ items and response options.
56 patients were enrolled. Mean age was 48.7 ± 12.3 years; 57% female; 80% Caucasian; mean duration of chronic pain was 11.2 ± 8.2 years with lower back pain predominating at 75%. Overall, the POMAQ was well-understood and received positive feedback. A few ( = 6, 11%) expressed concerns about completing the POMAQ using a secure internet site as they either indicated they were not computer savvy ( = 3, 5%) or were concerned about internet security ( = 3, 5%). Minor wording modifications were made to the POMAQ to enhance clarity and understanding of the POMAQ.
The POMAQ demonstrated content validity among patients with moderate to severe chronic pain and is undergoing psychometric evaluation among a larger cohort of patients.
在开发患者报告的工具时，内容验证至关重要，以确保相关性和可理解性。目的是通过对患有慢性中重度疼痛的成年人进行认知访谈，评估处方阿片类药物滥用和误用问卷（POMAQ）的患者理解程度。
这项定性研究涉及在一个临床诊所进行一次性的一对一认知访谈，参与者为来自四个组的慢性中重度疼痛患者：（1）已知阿片类药物滥用；（2）已知滥用其他物质（如酒精、苯二氮䓬类药物）；（3）阿片类药物非滥用；（4）无慢性阿片类药物使用。患者从 6 个美国临床中心招募。访谈开始时询问有关误用和滥用的概念引出问题；患者通过网络界面完成 POMAQ，然后进行关于 POMAQ 项目和响应选项的认知访谈。
共纳入 56 名患者。平均年龄为 48.7±12.3 岁；57%为女性；80%为白种人；慢性疼痛持续时间平均为 11.2±8.2 年，下腰痛占主导地位，占 75%。总体而言，POMAQ 理解良好，收到了积极的反馈。少数患者（=6，11%）对使用安全的互联网网站完成 POMAQ 表示担忧，因为他们要么表示自己不精通计算机（=3，5%），要么担心互联网安全（=3，5%）。对 POMAQ 进行了少量（=6，11%）的措辞修改，以增强其清晰度和对 POMAQ 的理解。
POMAQ 在患有中重度慢性疼痛的患者中表现出内容有效性，目前正在更大的患者队列中进行心理测量评估。
