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用从野猪肠道分离出的黏液分解和非黏液分解菌株对无菌仔猪进行定殖及其对鼠伤寒沙门氏菌的干扰。

Colonization of Germ-Free Piglets with Mucinolytic and Non-Mucinolytic Strains Isolated from the Intestine of Wild Boar and Their Interference with Typhimurium.

作者信息

Splichalova Alla, Pechar Radko, Killer Jiri, Splichalova Zdislava, Bunesova Vera Neuzil, Vlkova Eva, Salmonova Hana Subrtova, Splichal Igor

机构信息

Laboratory of Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, 549 22 Novy Hradek, Czech Republic.

Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, 165 00 Prague, Czech Republic.

出版信息

Microorganisms. 2020 Dec 15;8(12):2002. doi: 10.3390/microorganisms8122002.

DOI:10.3390/microorganisms8122002
PMID:33333934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7765441/
Abstract

Non-typhoidal serovars are worldwide spread foodborne pathogens that cause diarrhea in humans and animals. Colonization of gnotobiotic piglet intestine with porcine indigenous mucinolytic RP36 strain and non-mucinolytic strain RP37 and their interference with Typhimurium infection were compared. Bacterial interferences and impact on the host were evaluated by clinical signs of salmonellosis, bacterial translocation, goblet cell count, mRNA expression of mucin 2, villin, claudin-1, claudin-2, and occludin in the ileum and colon, and plasmatic levels of inflammatory cytokines IL-8, TNF-α, and IL-10. Both bifidobacterial strains colonized the intestine comparably. Neither RP36 nor RP37 strains effectively suppressed signs of salmonellosis. Both strains suppressed the growth of . Typhimurium in the ileum and colon. The mucinolytic RP36 strain increased the translocation of . Typhimurium into the blood, liver, and spleen.

摘要

非伤寒血清型是全球范围内传播的食源性病原体，可导致人类和动物腹泻。比较了用猪源黏液溶解型RP36菌株和非黏液溶解型菌株RP37对无菌仔猪肠道的定殖情况以及它们对鼠伤寒沙门氏菌感染的干扰。通过沙门氏菌病的临床症状、细菌移位、杯状细胞计数、回肠和结肠中黏蛋白2、绒毛蛋白、闭合蛋白-1、闭合蛋白-2和闭合蛋白的mRNA表达以及炎性细胞因子IL-8、TNF-α和IL-10的血浆水平来评估细菌干扰和对宿主的影响。两种双歧杆菌菌株在肠道中的定殖情况相当。RP36和RP37菌株均未有效抑制沙门氏菌病的症状。两种菌株均抑制了鼠伤寒沙门氏菌在回肠和结肠中的生长。黏液溶解型RP36菌株增加了鼠伤寒沙门氏菌向血液、肝脏和脾脏的移位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/9173d28c2964/microorganisms-08-02002-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/8571bab67d4e/microorganisms-08-02002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/f0c35399fb34/microorganisms-08-02002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/05568debb333/microorganisms-08-02002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/c5b222ff4924/microorganisms-08-02002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/d49abb07b618/microorganisms-08-02002-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/a573f9dc9ae5/microorganisms-08-02002-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/5d3042817578/microorganisms-08-02002-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/9173d28c2964/microorganisms-08-02002-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/8571bab67d4e/microorganisms-08-02002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/f0c35399fb34/microorganisms-08-02002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/05568debb333/microorganisms-08-02002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/c5b222ff4924/microorganisms-08-02002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/d49abb07b618/microorganisms-08-02002-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/a573f9dc9ae5/microorganisms-08-02002-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/5d3042817578/microorganisms-08-02002-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/153d/7765441/9173d28c2964/microorganisms-08-02002-g008.jpg

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