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普通人群中生活方式因素与维生素E代谢物之间的关联。

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population.

作者信息

Martens Leon G, Luo Jiao, Meulmeester Fleur L, Ashrafi Nadia, van Eekelen Esther Winters, de Mutsert Renée, Mook-Kanamori Dennis O, Rosendaal Frits R, van Dijk Ko Willems, Mills Kevin, Noordam Raymond, van Heemst Diana

机构信息

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

出版信息

Antioxidants (Basel). 2020 Dec 15;9(12):1280. doi: 10.3390/antiox9121280.

DOI:10.3390/antiox9121280
PMID:33333950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7765431/
Abstract

The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary α-tocopheronolactone hydroquinone (α-TLHQ) and α-carboxymethyl-hydroxychroman (α-CEHC levels), as potential reflection of lipid oxidation. We conducted a cross-sectional study in the Netherlands Epidemiology of Obesity Study. Serum α-TOH, and urinary α-TLHQ and α-CEHC were quantified by liquid chromatography coupled with tandem mass spectrometry. Information on the lifestyle factors (sleep, physical activity (PA), smoking and alcohol) were collected through questionnaires. Multivariable linear regression analyses were performed to assess the associations between the lifestyle factors and α-TOH measures. A total of 530 participants (46% men) were included with mean (SD) age of 56 (6) years. Of the examined lifestyle factors, only poor sleep was associated with a higher serum α-TOH (mean difference: 4% (95% CI: 1, 7%)). Current smoking was associated with higher urinary α-CEHC (32%: (14%, 53%)), with evidence of a dose-response relationship with smoking intensity (low pack years, 24% (2, 52%); high pack years, 55% (25, 93%)). Moderate physical activity was associated with a lower α-TLHQ relative to α-CEHC (-17%: (-26, -6%), compared with low PA). Only specific lifestyle factors associate with vitamin E metabolism. Examining serum α-TOH does not provide complete insight in vitamin E antioxidant capacity.

摘要

抗氧化维生素E(α-生育酚,α-TOH)可保护脂质免受活性氧的氧化作用。我们推测生活方式因素与以尿α-生育酚醌氢醌(α-TLHQ)和α-羧甲基-羟基色满(α-CEHC水平)为标志的维生素E代谢相关,它们可能反映脂质氧化情况。我们在荷兰肥胖症流行病学研究中开展了一项横断面研究。采用液相色谱-串联质谱法定量测定血清α-TOH以及尿α-TLHQ和α-CEHC。通过问卷调查收集有关生活方式因素(睡眠、身体活动(PA)、吸烟和饮酒)的信息。进行多变量线性回归分析以评估生活方式因素与α-TOH测量值之间的关联。共纳入530名参与者(46%为男性),平均(标准差)年龄为56(6)岁。在所研究的生活方式因素中,只有睡眠质量差与血清α-TOH水平较高相关(平均差异:4%(95%CI:1,7%))。当前吸烟与尿α-CEHC水平较高相关(32%:(14%,53%)),且有证据表明与吸烟强度存在剂量反应关系(低吸烟包年数,24%(2%,52%);高吸烟包年数,55%(25%,93%))。与低身体活动水平相比,中等身体活动水平与较低的α-TLHQ相对于α-CEHC水平相关(-17%:(-26%,-6%))。只有特定的生活方式因素与维生素E代谢相关。检测血清α-TOH并不能完全了解维生素E的抗氧化能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7345/7765431/3c6c61858fb4/antioxidants-09-01280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7345/7765431/3c6c61858fb4/antioxidants-09-01280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7345/7765431/3c6c61858fb4/antioxidants-09-01280-g001.jpg

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Increased plasma levels of the lipoperoxyl radical-derived vitamin E metabolite α-tocopheryl quinone are an early indicator of lipotoxicity in fatty liver subjects.
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