Department of Production and Quality Control, Kikkoman Nutricare Japan Incorporation, Nihonbashikoamicho 3-11, Chuo, Tokyo 103-0016, Japan.
Department of Women's Health, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo, Tokyo 113-8510, Japan.
Nutrients. 2020 Dec 15;12(12):3833. doi: 10.3390/nu12123833.
Middle-aged and elderly women are affected by various symptoms and diseases induced by estrogen deficiency. Proanthocyanidins, widely present in many kinds of fruits and berries, have many beneficial effects, such as antioxidative, anti-inflammatory, and antimicrobial activities. We researched the effects of proanthocyanidins for middle-aged and elderly women, finding that it has been revealed in many clinical trials and cohort studies that proanthocyanidins contribute to the prevention of cardiovascular disease, hypertension, obesity, cancer, osteoporosis, and urinary tract infection, as well as the improvement of menopausal symptoms, renal function, and skin damage. Thus, proanthocyanidins can be considered one of the potent representatives of complementary alternative therapy.
中年和老年女性受到各种由雌激素缺乏引起的症状和疾病的影响。原花青素广泛存在于多种水果和浆果中，具有许多有益的作用，如抗氧化、抗炎和抗菌活性。我们研究了原花青素对中年和老年女性的影响，发现许多临床试验和队列研究已经表明，原花青素有助于预防心血管疾病、高血压、肥胖、癌症、骨质疏松症和尿路感染，以及改善更年期症状、肾功能和皮肤损伤。因此，原花青素可以被认为是补充替代疗法的有力代表之一。
