School of Medicine and Pharmacology Sir Charles Gairdner Hospital Unit, University of Western Australia, Perth, Western Australia, Australia.
PLoS One. 2013 Aug 5;8(8):e71166. doi: 10.1371/journal.pone.0071166. Print 2013.
Progression to chronic renal failure involves accelerated atherosclerosis and vascular calcification. Oxidative stress and endothelial dysfunction play a role in renal failure pathophysiology. In addition to improving vascular health and function, proanthocyanidins have been shown to exert renoprotective effects in animal models. Thus we hypothesize that proanthocyanidins may contribute to the maintenance of healthy renal function.
Determine the association of habitual proanthocyanidin intake with renal function and the risk of clinical renal outcomes in a population of elderly women.
948 women aged over 75 y, free of prevalent renal disease at baseline, were randomly selected from ambulant Caucasian women. Proanthocyanidin consumption was determined using a validated food frequency questionnaire and the United States Department of Agriculture proanthocyanidin food content database. Fasting serum cystatin C and creatinine were assessed at baseline. Renal failure hospitalisations and deaths were assessed over 5 years of follow-up through the Western Australia Data Linkage System.
Compared to participants with low consumption, participants in the highest tertile of proanthocyanidin intake had a 9% lower cystatin C concentration (P<0.001). High proanthocyanidin consumers were at 50% lower risk of moderate chronic kidney insufficiency, and 65% lower risk of experiencing a 5-year renal disease event (P<0.05). These relationships remained significant following adjustment for renal disease risk factors and diet-related potential confounders.
Increased consumption of proanthocyanidins was associated with better renal function and substantially reduced renal associated events, which has been supported by mechanistic and animal model data. Proanthocyanidin intake should be further examined as a dietary contributor to better renal health.
慢性肾衰竭的进展涉及动脉粥样硬化和血管钙化的加速。氧化应激和内皮功能障碍在肾衰竭发病机制中起作用。除了改善血管健康和功能外，原花青素已被证明在动物模型中具有肾脏保护作用。因此，我们假设原花青素可能有助于维持健康的肾功能。
确定习惯性原花青素摄入量与肾功能的关系，并确定在老年女性人群中临床肾脏结局的风险。
从 75 岁以上的非初发肾脏疾病的白人女性中随机选择 948 名女性。使用经过验证的食物频率问卷和美国农业部原花青素食物含量数据库来确定原花青素的摄入量。在基线时评估空腹血清胱抑素 C 和肌酐。通过西澳大利亚州数据链接系统在 5 年的随访中评估肾衰竭住院和死亡。
与低摄入量的参与者相比，原花青素摄入量最高的 tertile 的参与者胱抑素 C 浓度低 9%（P<0.001）。高原花青素消费者患中度慢性肾功能不全的风险降低 50%，发生 5 年肾脏疾病事件的风险降低 65%（P<0.05）。在调整了肾脏疾病危险因素和饮食相关潜在混杂因素后，这些关系仍然显著。
增加原花青素的摄入量与更好的肾功能相关，并显著降低了肾脏相关事件，这得到了机制和动物模型数据的支持。原花青素的摄入量应进一步作为改善肾脏健康的饮食因素进行研究。
