Dental School, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, 20132 Milano, Italy.
Nutrients. 2020 Dec 15;12(12):3836. doi: 10.3390/nu12123836.
The prevalence of coeliac disease in the general population is 0.5%-1%; however, most patients remain undiagnosed until adult age. In some cases, the onset is represented by sub-clinical signs, some of which can be found in the mouth. The aim of this research was to identify any associations between the clinical characteristics of coeliac disease and oral manifestations. A structured questionnaire was administered to a group of 237 individuals with coeliac disease. 100% of the subjects fully completed the questionnaire. Among them, 182 (76.7%) were female, 64 patients (27%) were aged 15 to 24 years, 159 (67%) were aged 25 to 55 and 14 (6%) were aged 56 and over. Significant associations were observed in caries prevalence and dentin sensitivity; in addition, an inappropriate diet was related to oral manifestations; following a gluten-free diet could be important to control the gingival bleeding levels and to manage oral symptoms associated to coeliac disease. In general, the presence of inflammatory symptoms in the mouth seems to be associated with general symptoms of inflammation related to coeliac disease.
乳糜泻在普通人群中的患病率为 0.5%-1%;然而,大多数患者直到成年后仍未被诊断出来。在某些情况下,其发病表现为亚临床症状,其中一些症状可在口腔中发现。本研究旨在确定乳糜泻的临床特征与口腔表现之间的任何关联。我们向一组 237 名乳糜泻患者发放了一份结构式问卷。所有受试者均完整填写了问卷。其中,182 名(76.7%)为女性,64 名患者(27%)年龄在 15 至 24 岁,159 名(67%)年龄在 25 至 55 岁,14 名(6%)年龄在 56 岁及以上。我们观察到龋齿患病率和牙本质敏感之间存在显著关联;此外,饮食不当与口腔表现有关;遵循无麸质饮食可能对控制牙龈出血水平和管理与乳糜泻相关的口腔症状很重要。总的来说,口腔炎症症状的存在似乎与乳糜泻相关的全身性炎症症状有关。