Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Department of Symptom Research, MD Anderson Cancer Center, University of Houston, Houston, TX, USA.
Health Qual Life Outcomes. 2020 Dec 17;18(1):389. doi: 10.1186/s12955-020-01629-0.
EQ-5D health state utilities (HSU) are commonly used in health economics to compute quality-adjusted life years (QALYs). The EQ-5D, which is country-specific, can be derived directly or by mapping from self-reported health-related quality of life (HRQoL) scales such as the PROMIS-29 profile. The PROMIS-29 from the Patient Reported Outcome Measures Information System is a comprehensive assessment of self-reported health with excellent psychometric properties. We sought to find optimal models predicting the EQ-5D-5L crosswalk from the PROMIS-29 in the United Kingdom, France, and Germany and compared the prediction performances with that of a US model.
We collected EQ-5D-5L and PROMIS-29 profiles and three samples representative of the general populations in the UK (n = 1509), France (n = 1501), and Germany (n = 1502). We used stepwise regression with backward selection to find the best models to predict the EQ-5D-5L crosswalk from all seven PROMIS-29 domains. We investigated the agreement between the observed and predicted EQ-5D-5L crosswalk in all three countries using various indices for the prediction performance, including Bland-Altman plots to examine the performance along the HSU continuum.
The EQ-5D-5L crosswalk was best predicted in France (nRMSE = 0.075, nMAE = 0.052), followed by the UK (nRMSE = 0.076, nMAE = 0.053) and Germany (nRMSE = 0.079, nMAE = 0.051). The Bland-Altman plots show that the inclusion of higher-order effects reduced the overprediction of low HSU scores.
Our models provide a valid method to predict the EQ-5D-5L crosswalk from the PROMIS-29 for the UK, France, and Germany.
EQ-5D 健康状态效用（HSU）常用于健康经济学计算质量调整生命年（QALY）。EQ-5D 是特定于国家的，可以通过直接导出或通过映射来自自我报告的健康相关生活质量（HRQoL）量表（如 PROMIS-29 概况）来获得。PROMIS-29 来自患者报告的结果测量信息系统，是自我报告健康的综合评估，具有出色的心理测量特性。我们试图找到最佳模型来预测英国、法国和德国的 PROMIS-29 与 EQ-5D-5L 之间的转换，并将预测性能与美国模型进行比较。
我们收集了 EQ-5D-5L 和 PROMIS-29 概况以及英国（n=1509）、法国（n=1501）和德国（n=1502）三个具有代表性的普通人群样本。我们使用逐步回归和向后选择来找到预测 EQ-5D-5L 转换的最佳模型，从所有七个 PROMIS-29 领域。我们使用各种预测性能指标，包括 Bland-Altman 图来检查 HSU 连续体上的性能，研究了所有三个国家观察到的和预测的 EQ-5D-5L 转换之间的一致性。
法国的 EQ-5D-5L 转换预测最佳（nRMSE=0.075，nMAE=0.052），其次是英国（nRMSE=0.076，nMAE=0.053）和德国（nRMSE=0.079，nMAE=0.051）。Bland-Altman 图表明，纳入高阶效应可减少低 HSU 得分的过度预测。
我们的模型为英国、法国和德国提供了一种从 PROMIS-29 预测 EQ-5D-5L 转换的有效方法。
