Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Research, North Zealand Hospital, Hillerød, Denmark.
Int J Chron Obstruct Pulmon Dis. 2020 Dec 9;15:3303-3311. doi: 10.2147/COPD.S275234. eCollection 2020.
Pain is a clinical complication to chronic obstructive pulmonary disease (COPD) that interferes negatively with physical activity level (PAL), quality of life (QOL) and pulmonary interventions. Yet, research in pain characteristics including prevalence, localization, and intensity in people with COPD are sparsely researched.
To investigate self-reported pain prevalence, localization and intensity of pain in people with and without COPD, and to investigate the association between pain intensity and PAL among participants with COPD.
Data were derived from the Danish Health and Morbidity Survey in 2017. The study population was restricted to individuals aged ≥35 years. Data included pain intensity assessed on the Numeric Rating Scale (NRS) and localization, PAL, QoL, sleep disturbance, comorbidities, sociodemographic and behavioral factors.
In all, 528 participants with COPD and 8184 participants without COPD (51% females, mean ±SD age 67.1±11.4 years) were analyzed. Pain prevalence within the past 14 days was significantly higher in participants with COPD vs nonCOPD (72.7% vs 57.7%, <0.001) and mainly located in the limbs, thorax, and lower back. COPD was associated with the prevalence of chronic pain (≥6 months) (OR: 2.78, 95%CI: 2.32; 3.34, <0.001). Participants with COPD reported a higher pain intensity compared to those with nonCOPD with a mean difference of 1.04 points (95%CI: 0.75; 1.32, <0.001) on the NRS. In the adjusted multiple logistic regression analysis, pain intensity was negatively associated with odds of being physical active (OR: 0.72, 95%CI: 0.61; 0.85, <0.001).
Pain is more prevalent in people with self-reported COPD. After adjustment for age and gender, COPD was associated with an elevated pain intensity. Sleep disturbance and multimorbidity had the most pronounced impacts on pain intensity in the multiple linear regression model. In participants with COPD, increased pain intensity was negatively associated with being physically active.
疼痛是慢性阻塞性肺疾病（COPD）的一种临床并发症，它会对体力活动水平（PAL）、生活质量（QOL）和肺部干预产生负面影响。然而，针对 COPD 患者疼痛特征（包括疼痛的患病率、定位和强度）的研究还很少。
调查有和无 COPD 人群中自我报告的疼痛患病率、定位和强度，并调查 COPD 患者中疼痛强度与 PAL 之间的关联。
数据来自 2017 年丹麦健康和发病率调查。研究人群仅限于年龄≥35 岁的个体。数据包括使用数字评分量表（NRS）评估的疼痛强度以及定位、PAL、QOL、睡眠障碍、合并症、社会人口学和行为因素。
共分析了 528 名 COPD 患者和 8184 名无 COPD 患者（51%为女性，平均年龄±标准差为 67.1±11.4 岁）。在过去 14 天内，COPD 患者的疼痛患病率明显高于非 COPD 患者（72.7% vs 57.7%，<0.001），疼痛主要位于四肢、胸部和下背部。COPD 与慢性疼痛（≥6 个月）的患病率相关（OR：2.78，95%CI：2.32；3.34，<0.001）。与无 COPD 患者相比，COPD 患者报告的疼痛强度更高，NRS 平均差异为 1.04 分（95%CI：0.75；1.32，<0.001）。在调整后的多项逻辑回归分析中，疼痛强度与体力活动的可能性呈负相关（OR：0.72，95%CI：0.61；0.85，<0.001）。
自我报告患有 COPD 的人群中疼痛更为普遍。在调整年龄和性别后，COPD 与疼痛强度升高相关。在多元线性回归模型中，睡眠障碍和多种合并症对疼痛强度的影响最大。在 COPD 患者中，疼痛强度增加与体力活动减少呈负相关。
